DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

By G. Ira, A. Pellicioli, Alitukiriza Balijja, Xuan Wang, Simona Fiorani, Walter Carotenuto, Giordano Liberi, D. Bressan, Lihong Wan, N. M. Hollingsworth and 2 more. Nature, 2004

774 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5fce16b16bf68215eddd9f4e7cd85e8acc6def9b

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Citations in the corpus

Systematic discovery of in vivo phosphorylation networks. (2007, background): “…for CDK1 and/or CDK2 (Figure 5) is interesting, as CDKs have previously been implicated in the DNA-repair response by experiments showing that inhibition of CDKs in budding yeast results in defects in DNA damage-induced arrest and in homologous recombination repair pathways (Ira et al., 2004).”
Repair of strand breaks by homologous recombination. (2013, background): “Resection of endonuclease-induced DSBs only occurs in S or G2 and is controlled by cyclin-dependent kinases (Ira et al. 2004).”
Playing the end game: DNA double-strand break repair pathway choice. (2012, background): “The phosphorylation of DSB repair proteins by cyclindependent kinases (CDKs) is central to this regulation, and CDK activity is required to promote efficient resection in both yeast and vertebrates (Ira et al., 2004; Jazayeri et al., 2006).”
Sources of DNA double-strand breaks and models of recombinational DNA repair. (2014, background): “Although NHEJ can occur throughout the cell cycle, it is especially important in the G1 stage, when a key initial step in HR, the 50 to 30 resection of DSB ends, is blocked (Aylon et al. 2004; Ira et al. 2004).”
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair (2008, background): “cerevisiae [34]; however, the precise nature and extent of DSB”
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double strand break ends (2008, positive): “Formation of 3 0 ssDNA tails also determines the switch from the nonhomologous end joining (NHEJ) to the HR pathway because NHEJ preferentially utilizes the unresected ends for ligation (Ira et al., 2004).”
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “Both GC and SSA require resection of DNA ends as an initial step in the repair process and this strand resection has been shown to be cell cycle regulated in yeast, being much reduced in G1 cells (Ira et al., 2004).”
Regulation of homologous recombination in eukaryotes (2010, background): “In yeast, end resection is primarily regulated by CDK-dependent phosphorylation of the Sae2 nuclease (74, 79) (Figure 3) (Table 1), which determines whether a DSB is channeled into NHEJ or HR.”
Surviving the breakup: the DNA damage checkpoint. (2006, background): “However, when prearrested in G2/M by nocodazole treatment, these same cells fail to generate the characteristic hyperphosphorylation of Rad53 that normally reflects checkpoint activation (57, 62).”
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, neutral): “Studies in yeast have shown that DNA end resection is regulated during the cell cycle by cyclin-dependent kinase 1 ( Cdk1 ; also known as Cdc28) (Ref”
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks (2006, background): “In budding yeast, CDK activity in S and G2 phases promotes the formation of RPA-coated ssDNA and subsequent activation of the ATR orthologue, Mec1 (ref”