Alan Ashworth
Molecular Biology · 2000–2020
A researcher in the Science corpus: 23 papers; trusts 13 researchers and is trusted by 20 researchers here, as inferred from the citation graph.
Subfields
- Molecular Biology — 257 citations into it; #2,306 of 17,773 by trust here, #731 by citations
- Genetics — 118 citations into it; #3,287 of 6,854 by trust here, #940 by citations
- Oncology — 117 citations into it; #122 of 1,698 by trust here, #97 by citations
- Cancer Research — 111 citations into it
- Cell Biology — 24 citations into it
- Physiology — 5 citations into it
Whom Alan Ashworth trusts overall
Their strongest outbound trust, strongest first, inferred from their citations.
- Jan H. J. Hoeijmakers
- M. Moynahan
- N. Turner
- W. Kaelin
- C. Lord
- M. Jasin
- Andrew Tutt
- S. West
- Michael Weller
- K. Rothkamm
Who trusts Alan Ashworth overall
- A. Mendes-Pereira
- Mark J. O'Connor
- C. Lord
- D. Jelovac
- S. Martin
- Yves Pommier
- Lisa A. Carey
- Jan H. J. Hoeijmakers
- D. Fruman
- R. Brough
Papers from Alan Ashworth's perspective
Ordered by how strongly the researchers Alan Ashworth trusts endorse each paper. Same corpus, a different order for every researcher.
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy (Nature)
- Sister chromatid gene conversion is a prominent double‐strand break repair pathway in mammalian cells (EMBO Journal)
- Biallelic Inactivation of BRCA2 in Fanconi Anemia (Science)
- The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin*
- BRCA2 is required for homology-directed repair of chromosomal breaks. (Molecules and Cells)
- Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma (Clinical Cancer Research)
- Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (EMBO Molecular Medicine)
- The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (Nature Cell Biology)
- Repeated observation of breast tumor subtypes in independent gene expression data sets (Proceedings of the National Academy of Sciences of the United States of America)
- Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM (Cancer Research)
Their papers
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) — 3,895 citations
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy (2005) — 6,462 citations
- BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. (2010) — 792 citations
- Resistance to therapy caused by intragenic deletion in BRCA2 (2008) — 1,036 citations
- The DNA damage response and cancer therapy (2012) — 1,734 citations
- Hallmarks of 'BRCAness' in sporadic cancers (2004) — 1,659 citations
- Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. (2009) — 3,580 citations
- BRCAness revisited (2016) — 1,160 citations
- A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. (2008) — 859 citations
- Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (2009) — 674 citations
- Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. (2006) — 1,299 citations
- FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer (2010) — 695 citations
- BRCA1 dysfunction in sporadic basal-like breast cancer (2007) — 618 citations
- A randomised phase III trial of carboplatin compared with docetaxel in BRCA1/2 mutated and pre-specified triple negative breast cancer “BRCAness” subgroups: the TNT Trial (2018) — 811 citations
- Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. (2010) — 991 citations
- Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. (2018) — 653 citations
- PARP Inhibitors: The First Synthetic Lethal Targeted Therapy (2017) — 2,440 citations
- Reprogramming human T cell function and specificity with non-viral genome targeting (2017) — 729 citations
- DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer (2015) — 1,991 citations
- Large-scale genotyping identifies 41 new loci associated with breast cancer risk (2013) — 1,135 citations