Mechanisms of DNA damage, repair and mutagenesis
By Nimrat Chatterjee, Graham C. Walker. Environmental and Molecular Mutagenesis, 2017
1,644 citations recorded by the source corpus.
Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease‐states. However, robust DNA repair and damage‐bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine‐tuning are known to destabilize cellular metabolic homeostasis, as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in genome instability. Because routinely used biological, physical and chemical agents impact human health, testing their genotoxicity and regulating their use have become important. In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue. Environ. Mol. Mutagen. 58:235–263, 2017. © 2017 Wiley Periodicals, Inc.
Subfields: Cancer Research, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/9a9719f75a055102de460fa5df9c5554eeb9c462
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Citations in the corpus
- DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “In the indirect pathway, endogenous or exogenous materials activate products such as free radicals(94,95) that can damage DNA.(96) Several types of DNA damage have been reported previously, as follows: (i) single-strand breaks; (ii) double-strand breaks (DSBs);(97) (iii) base damage; (iv) sugar dama”
- Biofilms: The Microbial “Protective Clothing” in Extreme Environments (2019, background): “The solar UV radiation comprises three types based on the range of wavelength: UV-A (320 to 400 nm), UV-B (290 to 320 nm), and UV-C (100 to 290 nm) [43].”