RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

By J. Fustin, M. Doi, Y. Yamaguchi, H. Hida, S. Nishimura, Minoru Yoshida, T. Isagawa, M. Morioka, H. Kakeya, I. Manabe and 1 more. Cell, 2013

881 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/d1c51039c4c980c794f1e1338088b818a53009b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Chuan He
2. Samie R. Jaffrey
3. Kate D. Meyer
4. Hailing Shi
5. Pedro J. Batista
6. Jiangbo W
7. Syuzo Kaneko
8. Masaaki Komatsu

In Plant Science

1. Howard Y. Chang
2. Ryuji Hamamoto

Citations in the corpus

• METTL3 promotes translation in human cancer cells (2016, background): “…circadian clock regulation, early embryonic development, and stem cell self-renewal and differentiation (Batista et al., 2014; Chen et al., 2015; Fustin et al., 2013; Geula et al., 2015; Iles et al., 2013; Lin and Gregory, 2014; Wang et al., 2014c; Zhao et al., 2014; Zheng et al., 2013)…”
• Rethinking m6A Readers, Writers, and Erasers (2017, background): “Additional physiological roles for m6A-mediated gene regulation that have been uncovered include regulation of circadian rhythms (Fustin et al. 2013), stem cell differentiation (Batista et al. 2014, Geula et al. 2015, Y. Wang et al. 2014), and noncoding RNA function (Patil et al. 2016).”
• YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017, background): “…to play critical roles in constitutive splicing as well as in processing-linked transport of cellular and viral mRNAs (Finkel and Groner, 1983; Fustin et al., 2013; Lichinchi et al., 2016; Stoltzfus and Dane, 1982), suggesting fundamental roles for mRNA methylation within the nucleus in…”
• Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases (2016, neutral): “…and erasers has been linked to problems in self-renewal of stem cells, circadian clock and developmental defects, obesity, synaptic signaling, and cancers (Ben-Haim et al., 2015; Chen et al., 2015; Fustin et al., 2013; Geula et al., 2015; Peng et al., 2016; Wang et al., 2014a; Zheng et al., 2013).”
• Gene2vec: gene subsequence embedding for prediction of mammalian N6-methyladenosine sites from mRNA (2018, background): “…modification is involved in numerous biological activities, including the differentiation and reprogramming of stem cells (Yue et al. 2015), translation and alternative splicing (Geula et al. 2015; Xu et al. 2018), circadian clock (Fustin et al. 2013), and cerebellar development (Wang et al. 2018).”
• m6A RNA modification controls cell fate transition in mammalian embryonic stem cells (2014, background): “METTL3 depletion also leads to elongation of the circadian clock (Fustin et al., 2013), suggesting a role for m6A in resetting the transcriptome.”
• A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015, background): “…to a plethora of studies, beginning in 2012, coupling m6A antibody precipitation of oligonucleotides derived from total mammalian and yeast cell polyA+ RNA to high-throughput sequencing (RNA-seq) (e.g., see Dominissini et al. 2012; Meyer et al. 2012; Fustin et al. 2013; Schwartz et al. 2013, 2014).”
• FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export (2019, neutral): “…of embryonic (Batista et al., 2014; Geula et al., 2015) and neural stem cells (Wang et al., 2018; Yoon et al., 2017), as well as complex behaviors and processes such as circadian rhythms (Fustin et al., 2013), stress response (Engel et al., 2018), and learning (Koranda et al., 2018).”