Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

By S. Shimizu, T. Kanaseki, N. Mizushima, Takeshi Mizuta, Satoko Arakawa-Kobayashi, Craig B. Thompson, Y. Tsujimoto. Nature Cell Biology, 2004

1,462 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4417c5651e5abd05cf452af301c76cc816b6d814

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Citations in the corpus

Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “of autophagic cell death, which is necessary under certain conditions, such as in apoptosis-defective cells [210], is”
Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “Knockdown of the essential autophagy gene (Atg) products beclin-1 ( BECN1 ; Atg6 in yeast) and ATG5 reduced the etoposide-induced cell death of Bax −/− Bak −/− MEF”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “In some cases, when apoptosis is compromised, such as in the setting of Bax/Bak deficiency, activation of autophagy leads to cell death (47), presumably via self-cannibalization or bioenergetic failure.”
Bcl-2 family proteins and cancer (2008, background): “In this regard, Bcl-2 and Bcl-XL suppress autophagy by binding the protein beclin 1 (Atg6), an essential component of the mammalian autophagy system that marks autophagic vesicles for fusion with lysosomes (Shimizu et al., 2004; Pattingre et al., 2005) (Figure 1c).”
Autophagy regulates programmed cell death during the plant innate immune response. (2005, background): “In addition, atg5 and beclin 1 are required for etoposide and staurosporine treatment-induced cell death in apoptosisresistant Bax/Bak double knockout mouse embryonic fibroblasts (Shimizu et al., 2004).”
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis (2006, background): “Therefore, autophagic cell death has been considered as a “fail-safe” mechanism under conditions in which apoptosis does not wor”
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity (2010, background): “As the concept of autophagic cell death has been supported by the knockdown of Atg gene”
Cell death in the nervous system (2006, background): “Although the roles of the autophagic process in protein and organellar degradation, and in cellular protection during nutrient starvation, are well accepted, the role of autophagy in PCD is more controversia”
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. (2006, background): “…against beclin1 (50-AACUUGCUUUAC UCUCUCUAUCA-30) (Shimizu et al., 2004) (Figure S2) or (50-CAGUUUGGCA CAAUCAAUAUU-30) (Hoyer-Hansen et al., 2005) (Figure 3), murine atg5 (50- AAGAUCCUGGACCGGUCACC-30) (Shimizu et al., 2004), and LaminA/C were obtained from Dharmacon Research (Lafayette, CO).”
Role of autophagy in cancer (2007, background): “Cytotoxic drug treatment often triggers autophagy, particularly in apoptosis-defective cells, and the excessive cellular damage and attempt to remediate that damage through progressive autophagy can promote autophagic cell deat”