The NLR gene family: a standard nomenclature.
By J. Ting, Ruth C. Lovering, E. Alnemri, J. Bertin, J. Boss, B. Davis, R. Flavell, S. Girardin, Adam Godzik, J. Harton and 14 more. Immunity, 2008
933 citations recorded by the source corpus.
Iimmune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, cryopyrin/NALP3 are members of a family characterized by the presence of a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). Members of this gene family encode a protein structure similar to the NB-LRR subgroup of disease-resistance genes in plants and are involved in the sensing of pathogenic products and the regulation of cell signaling and apoptosis. Several members of this family have been associated with immunologic disorders. NOD2 for instance is associated with both Crohn's disease and Blau syndrome. A variety of different names are currently used to describe this gene family, its subfamilies and individual genes, including CATERPILLER (CLR), NOD-LRR, NACHT-LRR, CARD, NALP, NOD, PAN and PYPAF, and this lack of consistency has led to a pressing need to unify the nomenclature. Consequently, we collectively propose the family designation NLR (nucleotide-binding domain and leucine-rich repeat containing) and provide unique and standardized gene designations for all family members.
Subfields: Emergency Medical Services, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4331f99b750162a101c44204463d687b1cc6a9f2
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Citations in the corpus
- Caspase functions in cell death and disease. (2013, background): “Activated caspase-1 in turn cleaves pro-IL-1b and pro-IL-18, which facilitates the secretion of these proinflammatory cytokines (Ting et al. 2008b).”
- Inflammation and its role in age-related macular degeneration (2016, background): “These receptors commonly contain three main domains: (1) N-terminal acidic transactivation domain (NLRA proteins), baculoviral inhibitory repeat (BIR)-like domain (NLRB proteins), caspase recruitment domain (CARD; NLRC proteins), or pyrin domain (PYD; NLRP proteins) that either recruit adaptor, inte”
- The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis (2009, background): “The NLR family is composed of 23 family members in humans, whereas the mouse genome contains at least 34 NLR-encoding gene”
- Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “NLRP3 belongs to the NLR protein family, which includes 22 members in humans and at least 34 members in the mouse [8].”
- Pyroptosis in inflammatory diseases and cancer (2022, background): “ASC: apoptosis-associated speck-like protein containing a caspase recruitment domain; AD: alzheimer’s disease; AIM2: absent in melanoma 2; AMPCP: α, β-methylene adenosine 5’ diphosphate; AOZN: AMPCP and Orz loaded nanomicelles; ATP: adenosine triphosphoric acid; Aβ: β-amyloid protein; BNP: biomimeti”
- Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “NLRP3 belongs to the family of NLR (nucleotidebinding domain and leucine-rich repeat containing) proteins (24) implicated in inflammation and apoptosis, providing an additional clue as to its function.”
- Fatty acid-induced NLRP3-PYCARD inflammasome activation interferes with insulin signaling (2011, positive): “as key inducers of IL-1β generation and NLRP3 (nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3”
- Function of Nod‐like receptors in microbial recognition and host defense (2009, neutral): “E) based on the class of N-terminal effector domain has been recently proposed and approved by the Human Genome Organization Gene Nomenclature Committee (17).”