Genetic pathways that regulate ageing in model organisms

By L. Guarente, C. Kenyon. Nature, 2000

1,385 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/42eb47797fe541dd1e9ebe46f31df3cbda9e66ec

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In Aging

In Molecular Biology

Citations in the corpus

A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “Reduced signaling of the growth hormone/IGF-1 axis extends health- and lifespan in rodents (Brown-Borg, 2009; Guarente and Kenyon, 2000; Harrison et al., 2009; Junnila et al., 2013; Wullschleger et al., 2006).”
Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D (2002, background): “They represent mammalian orthologues of a Caenorhabditis elegans transcription factor, DAF-16, which in the worm regulates longevity and responses to environmental stress (14, 18).”
Kin Selection and the Evolutionary Theory of Aging (2007, background): “First, recent discoveries demonstrate that some of the molecular pathways affecting aging are influenced by single genes and are conserved across a very broad phylogenetic span (Arking 2006, Guarente & Kenyon 2000).”
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling (2001, neutral): “elegans is regulated by a conserved insulin/IGF-1 signaling pathwa”
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. (2002, background): “cerevisiae cells and aging in animals (37,38), but its function in plants remains unknown.”
Epigenetics and aging (2016, background): “2016; 2 : e1600584 29 July 2016 complexity of the process of aging and the influence of overlapping pathways on the outcome (22, 23).”
Autophagy in the pathogenesis of disease. (2008, neutral): “The notion that intermittent fasting promotes longevity is not merely a cultural belief shared by diverse civilizations throughout history; it is a scientific truth that extends across eukaryotic organisms, including yeast, flies, worms, and rodents (Guarente and Kenyon, 2000).”
SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress (2010, background): “Sirtuin genes are the human and murine homologs of the Saccharomyces cerevisiae Sir2 gene, which has been shown to regulate both replicative and overall life span (Guarente and Kenyon, 2000).”
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “Studies in a variety of organisms have identified single gene mutations that influence life span (Guarente and Kenyon, 2000).”
Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population (2014, neutral): “…and RAS-cAMP-PKA, promoted aging in multiple model organisms, thus providing evidence for the conserved regulation of aging by pro-growth nutrient signaling pathways (Fabrizio et al., 2001; Guarente and Kenyon, 2000; Kapahi and Zid, 2004; Kenyon, 2005, 2011; Longo, 1999; Tatar et al., 2001).”