Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

By Li Yu, A. Alva, H. Su, P. Dutt, E. Freundt, S. Welsh, Eric H. Baehrecke, M. Lenardo. Science, 2004

1,324 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/42995cfaa387ea2f6b8fdf4cb6f779fdcb0bc200

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Citations in the corpus

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. (2008, background): “a Cellular Necrotic Cell Death Pathway”
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis (2007, background): “It has been shown that inhibition of apoptosis (type I programmed cell death; PCD) by treatment with a caspase inhibitor triggers type II PCD, also known as autophagic cell death, in L929 fibroblast”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, neutral): “necrosis was observed [50,51].”
Autophagy and signaling: their role in cell survival and cell death (2005, background): “Jun N-terminal kinase (JNK) Autophagic cell death has been observed in fibroblasts and monocytoid cells in response to the inhibition of caspase-8.(82)”
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1 (2007, background): “…Organization The EMBO Journal VOL 26 | NO 10 | 2007 EMBO THE JOURNAL 2527 pro-apoptotic MOMP or caspase activation are blocked (Shimizu et al, 2004; Yu et al, 2004), and restoration of normal Beclin-1 levels in Beclin-1 deficient tumor cells can facilitate the induction of cell death by…”
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells (2005, background): “Similarly, in systems utilizing transfectable cells, RNA interference can be a tool for identifying key players in pathways leading to cell death (143).”
Autophagy regulates programmed cell death during the plant innate immune response. (2005, background): “The autophagy genes beclin 1 and atg7 are required to induce nonapoptotic cell death in the murine fibroblast L929 cells treated with capsase inhibitor zVAD (Yu et al., 2004).”
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis (2006, background): “Therefore, autophagic cell death has been considered as a “fail-safe” mechanism under conditions in which apoptosis does not wor”
Eaten alive: a history of macroautophagy (2010, background): “provided the first evidence that when apoptosis is compromised, activation of autophagy leads to cell deat”
Do inducers of apoptosis trigger caspase-independent cell death? (2005, methodology): “When this activity was inhibited by treatment with zVAD-fmk, some cells underwent a CICD programme that required RIP and JNK functio”
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. (2007, background): “Two observations that argue in favor of autophagy as a reflection of the therapeutic efficacy of antineoplastic agents are (a) that persistent activation of autophagy can lead to programmed cell death (5) and (b) that the autophagy regulator beclin 1 (BECN1) is a haploinsufficient tumorsuppressor ge”