Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat.

By T. Madsen, P. Kristjansen, T. Bolwig, G. Wörtwein. 2003

511 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Genetics

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “, but not in studies using other knockdown methods to prevent neurogenesi”
Synapse formation on neurons born in the adult hippocampus (2007, background): “, new neurons are functional and may be important in hippocampus-dependent learnin”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, unknown): “formance on hippocampal-dependent tasks have been reported (Madsen et al., 2003; Leuner et al., 2006; Wojtowicz, 2006).”
Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis (2006, background): “In contrast, depletion of new neurons does not affect spatial navigation learning (Shors et al., 2001; Madsen et al., 2003; Raber et al., 2004; Snyder et al., 2005), although there are effects on retention (Snyder et al., 2005).”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, unknown): “water maze or contextual fear conditioning [24,26,34,35].”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, unknown): “Studies looking for impairment after loss of adult neurogenesis have not found evidence that young granule neurons are needed for acquisition in the water maze (Shors et al., 2002; Madsen et al., 2003; Snyder et al., 2005; Saxe et al., 2006).”
Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival. (2013, background): “…with regards to neurogenesis and some hippocampal dependent tasks, it is noteworthy that novel object recognition, which was unaltered in our paradigm, is not affected by ablation (Madsen et al., 2003, Rola et al., 2004, Clelland et al., 2009) or enhancement of neurogenesis (Sahay et al., 2011).”
Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory (2004, background): “F, 4).”
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, background): “…memory, several investigators have reported that neurogenesis depletion does not affect spatial navigation learning in a water maze (Shors et al., 2002; Madsen et al., 2003; Snyder et al., 2005), but does disrupt longterm spatial memory on similar tasks (Madsen et al., 2003; Snyder et al., 2005).”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, methodology): “Every sixth section was sampled simultaneously for free-floating BrdU immunoperoxidase staining, as previously described (Madsen et al., 2003) using mouse anti-BrdU primary antibody (1 : 100, BD Transduction Laboratories) and rat adsorbed horse anti-mouse secondary antibody (1 : 200, Vector…”
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, methodology): “col that does not lead to long-term memory in naı̈ve rats, but we did find that MAM does not affect short-term recognition memory, confirming that short-term recognition memory does not require neurogenesis (Madsen et al., 2003; Raber et al., 2004).”
Mechanisms and functional implications of adult neurogenesis. (2008, unknown): “However, defective object recognition memory was not detected in irradiated or MAM-treated rats in a simpler context (Bruel-Jungerman et al., 2005; Madsen et al., 2003).”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, result): “In any case, that 1- to 2-weekold neurons are sensitive to the occurrence of LTP in the DG long before their functional maturation is completed, is consistent with the idea derived from learning experiments that they already present a range of functional properties at early stages (Shors et al., 200”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “…efforts are currently being devoted to study the influence of behavior on the rate of adult neurogenesis and the physiological relevance of adult neurogenesis in hippocampal function (van Praag et al., 2000; Shors et al., 2001; Madsen et al., 2003; Santarelli et al., 2003; Schinder and Gage, 2004).”
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, unknown): “…the physiological significance of adult neurogenesis, given that previous behavior studies on Neuron 54, 559–566, May 24, 2007 ª2007 Elsevier Inc. 563 the function of adult neurogenesis largely focused on immature neurons younger than 1 month old (Madsen et al., 2003; Snyder et al., 2005).”