A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.

By S. Ge, Chih-hao Yang, K. Hsu, Guo-li Ming, Hongjun Song. 2007

960 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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In Developmental Neuroscience

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Furthermore, NR2B is specially required for enhanced synaptic plasticity of newborn dentate granule cells during the critical period (Figure 3B) (Ge et al., 2007; Snyder et al., 2001).”
Dynamics of hippocampal neurogenesis in adult humans (2013, positive): “The newborn neurons have enhanced synaptic plasticity for a limited time after their differentiation (Ge et al., 2007; Schmidt-Hieber et al., 2004), which is critical for their role in mediating pattern separation in memory formation and cognition in rodents (Clelland et al., 2009; Nakashiba et…”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “Giachino C, Barz M, Tchorz JS, Tome M, Gassmann M, Bischofberger J, et al. GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors.”
Is adult neurogenesis essential for olfaction? (2011, neutral): “19 9 Geffen, M.N. et al. (2009) Neural encoding of rapidly fluctuating odors.”
Directed differentiation of hippocampal stem/progenitor cells in the adult brain (2008, background): “Newborn neurons go through distinct developmental steps, beginning with the division of a parental neural stem cell, before they become functionally integrate”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, neutral): “2; Ge et al., 2007, 2008).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “In addition, synaptic plasticity is enhanced: adult-born neurons have reduced LTP induction thresholds and increased LTP amplitude, which is at least partially attributable to a higher contribution of the NR2B-receptor subtype to NMDAR-mediated currents and less feed-forward inhibition at this devel”
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning (2011, positive): “Newly generated neurons have transiently enhanced synaptic plasticit”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, background): “Furthermore, at the start of the simulation, all the GCs in the network were initialized as naı¨ve, with the network eventually maturing to an adult-like state.”
The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “Most adult-born neurons begin to receive excitatory synapses between 2 and 4 weeks of age (Esposito et al., 2005; Ge et al., 2006), and during this period are more likely to show long-term potentiation (LTP) than their mature counterparts (Ge et al., 2007).”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “…CA3 pyramidal cells from an early developmental stage, these specialized synapses are not fully mature until after the adultborn neurons are around 8-weeks old (Faulkner et al., 2008; Toni et al., 2008), when these neurons should no longer be hyperexcitable (Ge et al., 2007; Mongiat et al., 2009).”
Structural Plasticity and Hippocampal Function (2010, methodology): “Some studies suggest that young mature neurons do not retain their unique electrophysiological properties, eventually becoming part of the same functional population as old mature neurons (Ge et al. 2007, Laplagne et al. 2006).”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “Immature, adult-born granule cells are hyperexcitable and hyperplastic (Ge et al., 2007), and these cells may dominate the responses of the DG (Alme et al.”
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-born Dentate Granule Cells (2011, background): “Consistent with previous findings (Snyder et al., 2001; Ge et al., 2007), the average enhancement level of EPSCs in GFP DGCs was significantly higher than that in mature GFP cells.”