Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

By Y. Arita, S. Kihara, N. Ouchi, K. Maeda, H. Kuriyama, Y. Okamoto, M. Kumada, K. Hotta, M. Nishida, Masahiko Takahashi and 6 more. Circulation, 2002

727 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/418bf501a22b770960b924fcd3eb80b560dccfa4

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In Epidemiology

1. P. Scherer
2. Barry J. Goldstein
3. Rosario Scalia
4. Takashi Kadowaki
5. Toshimasa Yamauchi
6. M. Trujillo
7. I. Shimomura
8. Yuji Matsuzawa

In Immunology

1. Barry J. Goldstein
2. Rosario Scalia
3. P. Scherer

In Pulmonary and Respiratory Medicine

1. H. Fang
2. R. L. Judd

Citations in the corpus

• Recent advances in the relationship between obesity, inflammation, and insulin resistance. (2006, background): “In addition to its insulin-sensitising effects, adiponectin may have a protective effect on the vascular wall by acting early at several steps of the atherogenesis process: 1) modulation of endothelial adhesion molecules [74], 2) transformation of macrophages into foam cells [75] and 3) modulation o”
• Adipose tissue-derived factors: impact on health and disease. (2006, background): “formation through its ability to inhibit foam cell formation (145) and stimulate smooth muscle cell proliferation (146).”
• Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. (2003, background): “It also suppresses the proliferation and migration of vascular smooth muscle cells by reducing the effects of various growth factors, including platelet-derived growth factor (PDGF)-AA, PDGF-BB, and heparin-binding epidermal growth factor (HB-EGF), on the cells (24).”
• The role of the novel adipocyte-derived hormone adiponectin in human disease. (2003, background): “In cultured smooth muscle cells, adiponectin attenuated DNA synthesis induced by several growths factors, such as platelet-derived growth factor, heparin-binding epidermal growth factor-like growth factor (HB-EGF), basic fibroblastic growth factor and epidermal growth factor (19, 70 ).”
• Adiponectin: more than just another fat cell hormone? (2003, background): “It also inhibits proliferation of vascular smooth muscle cells (20) and concentrates within the vascular intima of catheter-injured vessels (21).”
• Mechanisms linking obesity with cardiovascular disease (2006, background): “This is certain to occur in the absence of adiponectin, which is known to reduce VSMC proliferation and migratio”
• Adiponectin and adiponectin receptors. (2005, background): “induced by growth factors including platelet-derived growth factor, heparin-binding epidermal growth factor (EGF)-like growth factor, basic fibroblast growth factor, and EGF, as well as cell proliferation and migration induced by heparinbinding EGF-like growth factor (64).”