CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

By K. Maloy, Laurence Salaun, R. Cahill, Gordon Dougan, N. J. Saunders, F. Powrie. Journal of Experimental Medicine, 2003

844 citations recorded by the source corpus.

CD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG)−/− mice as a model to study the ability of CD4+CD25+ TR cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell–independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4+CD25+ TR cells. T cell–independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4+CD25+ TR cells. Suppression of innate immune pathology was dependent on T cell–derived interleukin 10 and also on the production of transforming growth factor β. Thus, CD4+CD25+ TR cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/40fc5993518e14f9383ab83e320f81c03379e1f4

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In Immunology

1. A. O’Garra
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4. Wan-Wan Lin
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Citations in the corpus

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• CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses (2003, background): “The initial focus was on organ-specific autoimmunity, but immunopathological reactions to foreign exogenous antigens, including those expressed by microorganisms, are also influenced by Treg (3, 5, 6, 21).”