IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1
By P. Vieira, J. Christensen, S. Minaee, E. O'Neill, F. Barrat, A. Boonstra, T. Barthlott, Brigitta Stockinger, D. Wraith, A. O’Garra. Journal of Immunology, 2004
743 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/7a9a01055bc768a60c74298466618e93d9112495
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In Immunology
- Shimon Sakaguchi
- TA Wynn
- A. O’Garra
- C. Hawrylowicz
- R. Flavell
- M. Wilson
- Tomoyuki Yamaguchi
- T. Nomura
Citations in the corpus
- Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “Activation in the presence of vitamin D3 and dexamethasone can also induce Tr1 cell differentiation via stimulation of autocrine IL-10 production (23, 25).”
- Regulatory T cells and immune tolerance. (2008, background): “For example, they exhibit diminished proliferation in response to antigenic stimulation, exert cell contact-dependent suppression, scarcely produce IL-2, and display an activated cell-surface phenotype (Vieira et al., 2004).”
- Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. (2005, background): “The inhibitory activity of these cells was demonstrated in vivo, where adoptive transfer of IL-10– secreting Tregs inhibited the development of murine experimental allergic encephalomyelitis (25); and in vitro, where they inhibited the proliferation of naive T cells (26).”
- Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, positive): “Anti-CD25 antibodies block suppression Allergic responses can be down-modulated by the action of T reg cells, through suppressive mediators such as TGF(46) or IL-10 (47).”
- Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection (2007, background): “This mediator potently down-regulates APC functions (7–9) and is produced by Th2 lymphocytes (2), Tr1 cells (10), CD25+ (11, 12) and CD25− (13, 14) T reg cells, and Th1 cells (15), as well as B lymphocytes Conventional T-bet+Foxp3− Th1 cells are the major source of host-protective regulatory IL-10 d”