Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

By J. Adolfsson, R. Månsson, Natalija Buza-Vidas, Anne Hultquist, K. Liuba, Christina T. Jensen, David Bryder, Liping Yang, O. Borge, Lina A. Thoren and 5 more. Cell, 2005

1,317 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/197f1baaf06e28eb740f101674475b7f6d216ed4

How researchers see this paper

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In Genetics

1. A. Trumpp
2. S. Morrison
3. Irving L. Weissman
4. Derrick J. Rossi
5. E. Laurenti
6. Steffen Jung
7. Christopher K. Glass
8. Amos Tanay

In Immunology

1. A. Mildner
2. S. Morrison
3. Florent Ginhoux
4. J. Dick
5. Steffen Jung
6. Derrick J. Rossi
7. Irving L. Weissman
8. Christopher K. Glass

In Physiology

1. S. Morrison
2. Derrick J. Rossi
3. Steffen Jung
4. Christopher K. Glass
5. Florent Ginhoux
6. R. DePinho

Citations in the corpus

• Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. (2013, background): “…largely because LMPPs with both neutrophil-monocyte and lymphoid potentials, but little or nomegakaryocyte-erythroid potential (MkE), have been detected (Adolfsson et al., 2005; Lai and Kondo, 2006; Yoshida et al., 2006), suggesting that an alternative MkE differentiation pathway may exist.”
• Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007, background): “This analysis revealed that although GMP were uniformly low for both these markers, CMP could be subdivided into distinct CD150-negative and -positive populations, whereas MEP consisted of both CD150-positive and -negative cells as well as a large portion of cells expressing high levels of Endoglin ”
• SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors (2013, methodology): “Consistent with prior studies (Adolfsson et al., 2005), most Flt3LSK cells were contained within the HPC-1 population (Figures S2A and S5A) and the Flt3 subset of HPC-1 cells formed myeloid and/or B cells but not platelets or erythrocytes (Figures S6D and S6F).”
• Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities (2010, background): “Recent studies suggest a model in which these cell types are derived from a lymphoid-primed multipotential progenitor (LMPP) that subsequently gives rise to common lymphoid progenitor (CLP) and granulocyte-macrophage progenitor (GMP) cells (Adolfsson et al., 2005) (Figure 1A).”
• Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions (2015, neutral): “In fact, the top 25% of the most highly expressing Flk2 LSK cells have been called lymphoid-primed MPPs or LMPPs (Adolfsson et al., 2005).”