The spleen in local and systemic regulation of immunity
By V. Bronte, M. Pittet. Immunity, 2013
983 citations recorded by the source corpus.
Summary The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ for iron metabolism and erythrocyte homeostasis. However, immune and hematopoietic functions have been recently unveiled for the mouse spleen, suggesting additional roles for this secondary lymphoid organ. Here we discuss the integration of the spleen in the regulation of immune responses locally and in the whole body and present the relevance of findings for our understanding of inflammatory and degenerative diseases and their treatments. We also consider whether equivalent activities in humans are known, as well as initial therapeutic attempts to target the spleen for modulating innate and adaptive immunity.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/dfcd2cda9ad774f320fef9753fa9d279f1e048be
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In Immunology
Citations in the corpus
- Structure-function of the immune system in the spleen (2019, background): “INNATE CONTROL OF ADAPTIVE IMMUNITY TO INSULTS IN THE SPLEEN The functional importance of the spleen in controlling systemic infections is evidenced by splenectomized patients, who show decreased clearance of malaria-parasitized RBCs and are at greater risk of meningitis and sepsis after infection w”