Role of MicroRNAs in Plant and Animal Development

By James C. Carrington, V. Ambros. Science, 2003

1,830 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3fc13a2ab32a06059e4ac1252b8ad7ef72ead5a4

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Citations in the corpus

A miRNA involved in phosphate-starvation response in Arabidopsis. (2005, background): “miRNAs silence genes that have complementary or partially complementary sequences to the miRNAs by causing mRNA cleavage or translational repression [1, 2, 4].”
Plant microRNAs: new players in functional genomics (2013, neutral): “Introduction MicroRNAs (miRNAs) are endogenous, small, noncoding RNA molecules playing crucial roles in the regulation of gene expression at the post-transcriptional level in eukaryotes and viruses (Carrington and Ambros 2003; Bartel 2004; Schwab et al. 2005; Unver et al. 2009).”
Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha (2005, background): “…to be appreciated, it is generally believed that miRNAs regulate gene expression at the post-transcriptional level by inhibiting the expression of mRNAs bearing fully or partly homologous target sequences (Carrington and Ambros, 2003; Bartel, 2004; He and Hannon, 2004; Novina and Sharp, 2004).”
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. (2004, background): “microRNAs (miRNAs) are widespread among eukaryotes and represent key components of a conserved system of RNAbased gene regulation (Cullen 2002; Hutvagner and Zamore 2002b; Carrington and Ambros 2003; Cerutti 2003).”
Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3 (2006, background): “DISCUSSION The discovery of miRNAs in many plant and animal species, and the growing evidence that these molecules regulate the activity of genes involved in a wide range of developmental and physiological processes represent a significant advance in our understanding of the regulatory mechanisms th”
RNA regulation: a new genetics? (2004, background): “The phenomenon of RNAi, which is unique to eukaryotes, has now been shown to be central to plant and animal developmen”
Computational identification of microRNA targets (2004, background): “…sites in 3 untranslated regions of mature target mRNA in the cytoplasm and, by unknown mechanisms, to modulate (repress) translation of the target mRNA (for reviews, see Ambros, 2001; Moss and Poethig, 2002; Moss, 2002; Ambros, 2003; Carrington and Ambros, 2003 and Banerjee and Slack, 2002).”
Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences (2004, background): “MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that have generated much excitement recently (Eddy, 2001; Bartel and Bartel, 2003; Carrington and Ambros, 2003).”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “MicroRNAs and small interfering RNAs (siRNAs) are sequence-specific guides for gene silencing (4, 11, 13, 63, 93).”
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs (2005, neutral): “dtd" [ ]> MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animal”
Posttranscriptional Induction of Two Cu/Zn Superoxide Dismutase Genes in Arabidopsis Is Mediated by Downregulation of miR398 and Important for Oxidative Stress Tolerance[W] (2006, background): “…plants increased ozone tolerance (Pitcher and Zilinskas, 1996); MnSOD-overproducing plants showed improved tolerance against freezing, water deficit, winter survival (McKersie et al., 1993, 1996, 1999), andmethyl viologen–induced oxidative stress (Bowler et al., 1991; Slooten et al., 1995).”
Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis (2005, positive): “miRNAs have a well-documented role in allowing developmental regulationofmultigene families (Palatnik et al., 2003; Carrington and Ambros, 2003; Bartel, 2004).”
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies (2006, background): “MicroRNAs (miRNA) are a class of small non-coding RNAs encoded in the genomes of animals and plants [ 1- 4 ] that play a role in targeting messages of protein-coding genes for cleavage or translational repression [5,6].”