Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
By D. Morrison, T. Preston. Gut microbes, 2016
3,250 citations recorded by the source corpus.
ABSTRACT The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the natural ligands, has led to increased interest in SCFA as signaling molecules between the gut microbiota and the host. SCFA represent the major carbon flux from the diet through the gut microbiota to the host and evidence is emerging for a regulatory role of SCFA in local, intermediary and peripheral metabolism. However, a lack of well-designed and controlled human studies has hampered our understanding of the significance of SCFA in human metabolic health. This review aims to pull together recent findings on the role of SCFA in human metabolism to highlight the multi-faceted role of SCFA on different metabolic systems.
Subfields: Molecular Biology, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/c86719300f4524bae301527fc507e6eb55e6ca1d
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Citations in the corpus
- Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “Short-chain fatty acids (SCFAs) have attracted considerable attention for their role in human health [28].”
- The Controversial Role of Human Gut Lachnospiraceae (2020, background): “LD De novo lipogenesis and cholesterol genesis in the liver [86].”
- The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome (2020, background): “In addition, the fer entation of selected, often rapidly fer entable no -dig stible carbohydrates (NDC ) produces another organic acid-lactic a id [30].”
- Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Propionate and acetate travel largely intact across the epithelium to the liver, where a substantial portion of propionate is degraded while acetate is released into systemic circulation (Bloemen et al., 2009; Morrison and Preston, 2016).”
- The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health (2021, background): “Indeed, most of the previous reviews do not discuss in detail SCFAs23 nor their beneficial role in cardiometabolic health,20 nor how different types of diet can increase SCFAs production to improve the health of patients suffering from CMDs.21,22,24,25 In the present review, on the contrary, we spec”
- Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “First, SCFAs-producing taxa are usually commensal, beneficial bacteria, with a direct positive effect on the gut barrier and immunity beyond the production of SCFAs [55,114].”
- The Effects of Vegetarian and Vegan Diets on Gut Microbiota (2019, background): “Maintenance of the intestinal barrier prevents endotoxemia and the subsequent inflammatory effects (75, 76).”
- Formation of propionate and butyrate by the human colonic microbiota. (2017, background): “First, they differ in their fate and tissue distribution, with butyrate being used preferentially as an energy source by the gut mucosa, propionate contributing to gluconeogenesis in the liver and acetate achieving the highest systemic concentrations in blood (Morrison & Preston, 2016).”
- Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? (2021, background): “Next to being important cross-feeding products, these metabolites also beneficially affect the intestinal mucosa [4,5].”