Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.

By A. Newton. Biochemical Journal, 2003

851 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3edd5c3c178364f27bbf15fb66861e4942aa344d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. J. Blenis
2. Philippe P Roux
3. E. Murphy
4. R. Anjum
5. C. Steenbergen
6. D. Alessi
7. D. Komander
8. K. Guan

In Molecular Biology

1. David M. Sabatini
2. K. Guan
3. J. Blenis
4. R. Anjum
5. K. Inoki
6. Philippe P Roux
7. D. Komander
8. A. Newton

Citations in the corpus

• Cisplatin in cancer therapy: molecular mechanisms of action (2014, neutral): “Cisplatin and Protein Kinase C Protein kinase C [PKC] is a family closely related phospholipid dependent enzymes that play critical roles in signal transduction and cell regulation (Basu and Sivaprasad, 2007;Newton, 2003;Basu, 1993;Nishizuka, 1992).”
• The RSK family of kinases: emerging roles in cellular signalling (2008, background): “These sequences are termed the 'turn motif' and the 'hydrophobic motif', respectivel”
• Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. (2009, background): “Diacylglycerol is a known activator of novel PKC (51), and increases of both diacylglycerol and novel PKC activity are associated with lipid-induced insulin resistance (52, 53).”
• Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. (2008, background): “Despite its name, PDK1 is reported to be constitutively active (188).”
• The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation (2020, background): “Protein kinase C (PKC) is one of the key protein kinases mediating the cellular signaling pathway, which responds to cytokines, growth factors, and other messenger molecules [53].”
• PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005, background): “Akt is activated by sequential phosphorylation steps at two sites conserved within the AGC kinase family (Newton, 2003).”
• PDK1, the master regulator of AGC kinase signal transduction. (2004, background): “PDK1 is also thought to be the enzyme which phosphorylates the T-loop of all isoforms of protein kinase C (PKC) (reviewed in Ref.”
• Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (2008, background): “In contrast, phosphorylations of all three sites in PKC are constitutive, whereas binding of second messengers, such as DAG and calcium, to regulatory domain provides the major signal input for PKC activation (Parekh et al, 2000; Newton, 2003).”
• ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions (2004, background): “Of these, Ser363 and Ser380 are located within sequences conserved among most AGC kinases, the turn motif and hydrophobic motif, respectively (138).”