Aptamers and Their Biological Applications
By Kyung-Mi Song, Seonghwan Lee, Changill Ban. Italian National Conference on Sensors, 2012
707 citations recorded by the source corpus.
Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocellulose membrane filtration, affinity chromatography, magnetic bead, and capillary electrophoresis-based selection methods, are explained in detail. We also introduce various applications of aptamers for the diagnosis of diseases and detection of small molecules. Numerous analytical techniques, such as electrochemical, colorimetric, optical, and mass-sensitive methods, can be utilized to detect targets, due to convenient modifications and the stability of aptamers. Finally, several medical and analytical applications of aptamers are presented. In summary, aptamers are promising materials for diverse areas, not just as alternatives to antibodies, but as the core components of medical and analytical equipment.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9a14d9c634b531018b5c02dc82328300e71e88f6
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In Molecular Biology
Citations in the corpus
- Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, positive): “To prove and link gradient-dependent signals with the resulting developmental outcomes, recent biophysical approaches such as using nanosensors (Cullum and Vo-Dinh, 2000) and aptamers (Song et al., 2012) could be adopted to track the quantitative change in the putative morphogens and in the transcri”