Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

By S. Bao, Qiulian Wu, R. McLendon, Y. Hao, Q. Shi, Anita B. Hjelmeland, Mark W. Dewhirst, D. Bigner, Jeremy N. Rich. Nature, 2006

6,322 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/3df8176149af0eff0657a8da1ed43c1d3fe302cd

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Citations in the corpus

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2010, background): “As CSC have been shown to be relatively resistant to therap”
Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment (2017, background): “This observation converges with the higher predicted fraction of M2 macrophages in primary MES GBM relative to primary non-MES GBM.”
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “Similarly, CD133-expressing tumor cells isolated from both human glioma xenografts and primary patient glioblastoma specimens preferentially activate the DNA damage checkpoint in response to radiation and repair radiation-induced DNA damage more effectively than CD133-negative tumor cells [92].”
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, positive): “GSCs are often located in perivascular niches and interact with ECs in a bidirectional manner (Bao et al., 2006b; Calabrese et al., 2007).”
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, background): “Bao et al. have previously shown that stem-like CD133positive tumor cells in GBM are resistant to radiation therapy [ 41 ].”
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy (2015, background): “For instance, it was demonstrated that glioblastoma cancer stem cells (CD133+) showed higher DNA repair and decreased apoptosis in response to irradiation, compared to non-stem-cell-like (CD133-) population.(94,96,102) Hypoxia causes slow-proliferating stem-cell-like phenotype of cells, decreases se”
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance (2011, background): “An intriguing medical ramification of this concept was provided by studies of glioma-initiating cells, which were found to be more resistant to clastogen-induced DNA damage, possibly owing to a more relaxed epigenetic makeu”
let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, background): “Multiple mechanisms likely influence selective survival under chemotherapy, including preferential activation of DNA repair pathways in T-IC, as was shown for glioma (Bao et al., 2006).”
Integrin alpha 6 regulates glioblastoma stem cells (2010, methodology): “Glioblastoma stem cells (GSCs) are relatively radioresistant (Bao et al., 2006a) and chemoresistant (Liu et al., 2006).”
The biology of cancer stem cells. (2007, background): “Conversely, inhibition of c-src tyrosine kinase (CSK) homologous kinase (CHK), an enzyme involved in the activation of ATM, makes the normal and glioblastoma stem cells more sensitive to radiation (Bao et al. 2006).”
CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. (2007, background): “described previously (2, 8 ). All procedures were conducted in accordance with German laws governing animal care.”