The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
By Barbara Muz, Pilar de la Puente, F. Azab, Abdel Kareem Azab. Hypoxia, 2015
1,669 citations recorded by the source corpus.
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional vascularization and acquisition of epithelial-to-mesenchymal transition phenotype resulting in cell mobility and metastasis. Hypoxia alters cancer cell metabolism and contributes to therapy resistance by inducing cell quiescence. Hypoxia stimulates a complex cell signaling network in cancer cells, including the HIF, PI3K, MAPK, and NFĸB pathways, which interact with each other causing positive and negative feedback loops and enhancing or diminishing hypoxic effects. This review provides background knowledge on the role of tumor hypoxia and the role of the HIF cell signaling involved in tumor blood vessel formation, metastasis, and development of the resistance to therapy. Better understanding of the role of hypoxia in cancer progression will open new windows for the discovery of new therapeutics targeting hypoxic tumor cells and hypoxic microenvironment.
Subfields: Cancer Research, Molecular Biology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/b15f2647bf644c18610fbdc2b6ad07c02c02dc29
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In Cancer Research
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Citations in the corpus
- Gastric cancer: a comprehensive review of current and future treatment strategies (2020, background): “ulation of various bone morphogenic proteins (BMPs), within TCGA gastric cancer and GEO database cohorts, which these factors can signal for angiogenic markers [117].”
- A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer (2019, background): “This connection is therapeutically valuable and should be considered in developing novel therapies with an effect upon activated HIF-1α [81]; moreover, hypoxia regulates not only cancer progression through angiogenesis and metastasis but also the resistance to therapy [80].”