Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.

By Manel Esteller, Jose M. Silva, G. Domínguez, F. Bonilla, X. Matías-Guiu, E. Lerma, E. Bussaglia, J. Prat, I. Harkes, E. Repasky and 4 more. Journal of the National Cancer Institute, 2000

1,255 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3df128ca6b396a3e6e3b36120867aad3769d1323

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours (2002, background): “Selected examples are provided by the methylation-mediated silencing of the mismatch DNA repair gene hMLH1 in sporadic cases of colorectal, endometrial, and gastric tumours that cause the bizarre phenotype denominated microsatellite instability [19–23]; the promoter hypermethylation of MGMT [24] tha”
Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer (2015, background): “BRCA1 promoter hypermethylation has been reported in approximately 10% to 20% of HGSOCs and is mutually exclusive of BRCA1/2 mutations, suggesting that there is strong selective pressure to inactivate BRCA via either mutation or epigenetic silencing in this disease (16, 27, 28).”
Integrated Genomic Analyses of Ovarian Carcinoma (2011, neutral): “Raphael(28), Fabio Vandin(28), Peter W.”
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists (2011, background): “83 BRCA1 gene promoter is methylated in >60p of medullar”
Gene expression profiling predicts clinical outcome of breast cancer (2002, background): “The one sporadic tumour that was classified as a BRCA1 tumour was shown to contain methylation of the BRCA1 promoter, indicating an epigenetic modification of BRCA1”
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018, neutral): “, 2015), BRCA1 (Esteller et al., 2000), and HLTF (SMARCA3) (Moinova et al.”
BRCA1 dysfunction in sporadic basal-like breast cancer (2007, background): “The incidence of BRCA1 methylation has appeared to be more common in cancers with a high histological grade, and with a triple negative phenotype, suggesting that BRCA1 methylation could underlie basal-like cancers (Magdinier et al., 1998; Catteau et al., 1999; Esteller et al., 2000).”
Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer (2004, background): “Because the BRCA1 gene may also be inactivated somatically ( 21 ), it will be interesting to determine whether the presence of cytokeratin 5/6 is associated with the loss of BRCA1 protein of either germline or somatic origin.”