Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

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Hallmarks of 'BRCAness' in sporadic cancers (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3872">CK17”
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors (2007, background): “The finding that Brca1 loss (coincident with p53 mutation) in mice gives rise to tumors with a basal-like phenotype is notable because humans carrying BRCA1 germline mutations also develop basal-like tumors [3,32], and most human BRCA1 mutant tumors are p53-deficient [43,44].”
Triple-negative breast cancer: disease entity or title of convenience? (2010, background): “TNBC and the BRCA1 pathway The majority of tumors in BRCA1 mutation carriers are triple negative and show morphological and immunohistochemical similarities to BLBCs”
BRCA1 and BRCA2: 1994 and beyond (2004, background): “It is perhaps unsurprising, therefore, that BRCA1 -related breast cancers have a BASAL PHENOTYPE”
Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype (2005, result): “It is consistent with and expands on a recent small study reported by Foulkes et al. in which they reported that 15 of 17 (88%) BRCA1 tumors expressed CK5/6 ( 20 ).”
Clinical implications of the intrinsic molecular subtypes of breast cancer. (2015, background): “BRCA1-mutated breast cancer is associated with Basal-like disease [35,36].”