Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

By Manel Esteller, J. Herman. Journal of Pathology, 2002

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Ensembl regulation resources (2016, background): “These measurements can be used to identify regulatory elements (20–22), but also characterise disease (23).”
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer (2002, background): “Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of DAXX in acute promyelocytic leukaemia with t(15;17).”
The changing faces of glutathione, a cellular protagonist. (2003, background): “As an exception, epigenetic alterations may lead to a malignant tumor in childhood cancer (Esteller and Herman, 2002).”
DNA hypomethylation and human diseases. (2007, background): “97 Level of 5 meC is 56% lower in breast tumors; reduction methylation is less for BRCA1 (42%) and BRCA2 (30%) tumors HPCE (high performance capillary electrophoresis) %meC of total C [8] Sporadic cancer (n=13) 2.”
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “It is becoming increasingly apparent that the multiple changes in cancer cells, including chromosomal instability, activation of oncogenes, silencing of tumor suppressor genes and inactivation of DNA repair systems, are caused not only by genetic but also by epigenetic abnormalitie”
The Ensembl Regulatory Build (2015, background): “These alterations have been shown to provide crucial markers of developmental diseases [9] and cancer [10].”