The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses.

By G. Trinchieri, S. Pflanz, R. Kastelein. Immunity, 2003

1,001 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Differentiation of Effector CD4 T Cell Populations (2010, positive): “Defects in IL-12RB1 and IL-12B should block or diminish both Th1 and Th17 differentiation, because these receptor and cytokine chains are important in assembling both the IL-12 and IL-23 receptors and the IL-12 and IL-23 proteins (40, 293).”
The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “IL-12 plays an important role in differentiating and activating Th1 cells and is produced by activated macrophages, DCs, and airway epithelial cells (31).”
Immunity, Inflammation, and Cancer (2010, neutral): “A close relative of IL-23 is IL-12, which shares with IL-23 the IL-12p40 subunit and is involved in Th1 differentiation, IFNγ production, and activation of anti-tumor immunity (Trinchieri et al., 2003).”
Structural insights into the assembly and activation of the IL‐27 signaling complex (2022, background): “IL-27 is a heterodimeric cytokine composed of two gene products, Epstein – Barr virus-induced gene 3 (EBI3) and IL-27p28 (p28; Vignali & Kuchroo, 2012).”
CD4+T Cells: Differentiation and Functions (2012, background): “Interleukin 12 (IL12) and interferon γ (IFNγ) are the critical cytokines initiating the downstream signaling cascade to develop Th1 cells [19].”