The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

By Jun Oh, Rei Takahashi, S. Kondo, Akira Mizoguchi, Eijiro Adachi, R. M. Sasahara, Sachiko Nishimura, Yukio Imamura, H. Kitayama, D. Alexander and 10 more. Cell, 2001

712 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/3d62ba458fbbba97379e146bf644b1659ff3da4f

Citations in the corpus

• MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, neutral): “Concurring with previously published reports (12, 46), our data indicate that these MMP inhibitors regulate MMP activity posttranslationally.”
• Structure and function of matrix metalloproteinases and TIMPs. (2006, neutral): “MT1-MMP (MMP-14) has collagenolytic activity on collagens I, II, and III [33].”
• The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity (2010, neutral): “-14 and ADAM10 [119,120].”
• New functions for the matrix metalloproteinases in cancer progression (2002, neutral): “cgi?l=8434">RECK (reversion-inducing cysteine-rich protein with kazal motifs) is the only known membrane-bound MMP inhibito”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, neutral): “…protein with kazal motifs (RECK) is a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein expressed in many cells including vascular smooth muscle cells (VSMCs), and inhibits MMP-2, MMP-9 and MMP-14 when expressed in human fibrosarcoma-derived cell line HT1080 (Oh et al., 2001).”
• Extracellular matrix remodelling: the role of matrix metalloproteinases (2003, neutral): “It is the only cell surface MMP inhibitor characterized thus far [27].”
• Strategies for MMP inhibition in cancer: innovations for the post-trial era (2002, neutral): “cgi?l=8434">RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a cell-surface MMP inhibitor and a key regulator of ECM integrity and angiogenesi”
• Extracellular Matrix Communication and Turnover in Cardiac Physiology and Pathology (2015, neutral): “…expression of α 2-macroglobulin has been reported in endothelial cells within the cardiovascular tissue (141), information on the functional significance of this proteinase RECK (reversion-inducing-cysteine-rich protein with motifs) is a GPI-anchored glycoprotein with MMP inhibitory capacity (302).”
• Gelatinase-mediated migration and invasion of cancer cells. (2005, neutral): “Interestingly, in contrast to MMP deficient animals, deletion of a functional RECK gene is lethal (Oh et al., 2001).”
• Progress in matrix metalloproteinase research. (2008, neutral): “Several other proteins have been reported to inhibit selected members of MMPs: a secreted form of β-amyloid precursor protein inhibits MMP-2 (Higashi and Miyazaki, 2003); A Cterminal fragment of procollagen C-proteinase enhancer protein inhibits MMP-2 (Mott et al., 2000); and RECK, a GPI-anchored gl”
• Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, neutral): “The physiological relevance of other inhibitors including the RECK protein (204) is unknown.”
• Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. (2008, neutral): “More selective MMP inhibitors include the pyrimidine-2,4,6-trione derivative Ro-28-2653, which selectively inhibits MMP-2, MMP-9, and MT1-MMP, Ro-28-3555 (trocade), selective inhibitor of MMP-1 [101], and IW449, selective inhibitor of MMP-2 [100].”
• Cysteine‐rich domains related to Frizzled receptors and Hedgehog‐interacting proteins (2012, neutral): “RECK plays an essential role in development, and it can suppress tumor invasion and metastasis by acting as inhibitors of several matrix metalloproteases that break down extracellular matrix.(41,42)”
• Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade (2013, neutral): “In contrast, only membrane-bound RECK protein inhibited secretion of proMMP-9 (Oh et al., 2001; Rhee & Coussens, 2002).”
• Surface engineering approaches to micropattern surfaces for cell-based assays. (2006, neutral): “, fibronectin), dynamic events such as cell-surface remodeling by enzymes, cell-induced mechanical tensions as well as synthesized ECM proteins will together alter the interfacial protein layer [129,130].”