Development by self-digestion: molecular mechanisms and biological functions of autophagy.

By Beth Levine, D. Klionsky. Developmental Cell, 2004

3,921 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3d121410702ab9c1efe10b083110d364eb272b20

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Citations in the corpus

Hierarchy of Atg proteins in pre‐autophagosomal structure organization (2007, background): “Macroautophagy (autophagy) is a degradation process ubiquitously observed in eukaryotes, playing important roles in cell survival, cell remodeling and intracellular clearance in higher eukaryotes (Levine & Klionsky 2004; Shintani & Klionsky 2004a).”
HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy (2010, background): “…characterization of ATG genes essential for autophagy has yielded critical insight into the mechanism of autophagy activation and autophagosome formation (reviewed by Levine and Klionsky, 2004), whether and how the fusion of autophagosomes to lysosomes is controlled remain poorly understood.”
The regulation of autophagy – unanswered questions (2011, background): “In addition to stress management, autophagy is involved in normal development (Levine and Klionsky, 2004), senescence (Young et al.”
Another way to die: autophagic programmed cell death (2005, neutral): “This issue has been addressed by some recent reviews.(19,20) However, an important point to remember is that the existing evidence about the role of autophagic death in physiological and”
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (2008, background): “Autophagy is an evolutionarily conserved cellular pathway in which the cell sequesters cytoplasmic contents in a doublemembrane vesicle and delivers them to the lysosome for degradation (Levine and Klionsky, 2004).”
Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “Autophagy is a physiological process by which long-lived proteins, ribosomes, lipids and even entire cellular organelles are engulfed by double-membrane structures, which are subsequently targeted to lysosomes for degradation [108].”
Nrf2, the Master Regulator of Anti-Oxidative Responses (2017, background): “This intracellular bulk degradation is executed through engulfment by double-membrane vesicles, named autophagosomes, which fuse with lysosomes [19].”
Autophagy and signaling: their role in cell survival and cell death (2005, background): “According to the authors,40 amino acids use an mTOR-independent pathway which is initiated by binding one or more amino acids, presumably leucine, to an aminoacid receptor protein in the plasma membrane, which then somehow leads to an inhibition of autophagy that is independent of mTOR.”
Atg8 controls phagophore expansion during autophagosome formation. (2008, background): “In multicellular organisms, autophagy has important roles in development, immune defense, programmed cell death, tumor suppression, and the prevention of neuronal degeneration (Levine and Klionsky, 2004; Shintani and Klionsky, 2004a; Boland and Nixon, 2006; Schmid and Münz, 2007).”