JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

By Yongjie Wei, S. Pattingre, Sangita C. Sinha, Michael C. Bassik, Beth Levine. Molecules and Cells, 2008

1,349 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Plant Science

View Paper: https://www.semanticscholar.org/paper/03da193d4dcccd4a50c82abcc22a4dd6f17b611a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Beth Levine
2. D. Klionsky
3. Guido Kroemer
4. N. Mizushima
5. I. Slaninová
6. Douglas R. Green
7. V. Deretic
8. Alec C. Kimmelman

In Immunology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Michael Lotze
5. D. Tang
6. R. Kang
7. H. J. Zeh
8. Douglas R. Green

In Plant Science

1. Beth Levine
2. Douglas R. Green
3. Guido Kroemer
4. N. Mizushima
5. D. Klionsky
6. L. Galluzzi
7. Alec C. Kimmelman
8. Guillermo Mariño

Citations in the corpus

• ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase (2013, methodology): “Active GST-ULK1 (1-649) and GST-ULK2 (1-478) from insect cells was purchased from CQuential Solutions (Moraga, CA).”
• Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “Autophagy is induced by the release of BECN1 from BCL2 by pro-apoptotic BH3 proteins, phosphorylation of BECN1 by DAPK (at Thr119, located in the BH3 domain),(426) or phosphorylation of BCL2 by JNK1 (at Thr69, Ser70 and Ser87).(427,428) The relationship between BECN1 and BCL2 is more complex in deve”
• Autophagy in malignant transformation and cancer progression (2015, positive): “Along similar lines, RAS activates mitogen-activated protein kinase 8 (MAPK8, best known as JNK1) and nuclear factor, erythroid 2-like 2 (NFE2L2, best known as NRF2), thereby promoting autophagy via the JNK1-dependent phosphorylation of BCL2 (and the consequent derepression of BECN1), and the NRF2-d”
• Autophagy in the Cellular Energetic Balance (2011, positive): “Starvation-induced c-jun N-terminal kinase (JNK) activation leads to Bcl-2 phosphorylation that makes Beclin-1 accessible for macroautophagic activation (Wei et al., 2008).”
• Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms (2009, background): “The autophagy regulatory protein Beclin1 has been shown to bind to BCL-2, and phosphorylation of BCL-2 by JNK1 has been proposed to cause Beclin1 to dissociate from BCL-2, thereby promoting a protective form of autophagy (Wei et al., 2008).”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, result): “trasts with results reported by Wei and co-workers (315, 316) showing that JNK promotes autophagy by triggering the interaction of Bcl2 with Beclin-1.”