Metabolic Interactions in the Tumor Microenvironment
By C. Lyssiotis, Alec C. Kimmelman. Trends in Cell Biology, 2017
761 citations recorded by the source corpus.
Tumors are dynamic pseudo-organs that contain numerous cell types interacting to create unique physiology. Within this network, the malignant cells encounter many challenges and rewire their metabolic properties accordingly. Such changes can be experienced and executed autonomously or through interaction with other cells in the tumor. The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism. They include symbiotic nutrient sharing, nutrient competition, and the role of metabolites as signaling molecules. Examples of such processes abound in normal organismal physiology, and such heterocelluar metabolic interactions are repurposed to support tumor metabolism and growth. The importance and ubiquity of these processes is just beginning to be realized, and insights into their role in tumor development and progression are being used to design new drug targets and cancer therapies.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bb565b13f7fcefd7541768aba57dacd3dc8028ad
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In Cancer Research
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In Molecular Biology
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Citations in the corpus
- Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “The high utilization of glucose by cancer cells results in the accumulation of extracellular lactate affecting a number of cell types within the tumor microenvironment (TME), composed by a variety of different cell types such as endothelial cells, cancerassociated fibroblasts (CAFs), immune cells an”
- Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation (2018, background): “Themicroenvironment of a tumor, considered as a pathologically formed ‘‘organ,’’ is frequently characterized by hypoxia, as well as by abnormal levels of various cytokines, growth factors, and metabolites (Lyssiotis and Kimmelman, 2017).”