Argonaute2 Is the Catalytic Engine of Mammalian RNAi

By Jidong Liu, M. Carmell, Fabiola V. Rivas, C. Marsden, J. Thomson, Ji‐Joon Song, Scott M. Hammond, L. Joshua-Tor, Gregory J. Hannon. Science, 2004

2,868 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c4fbd16d3c9fbb228aab471d1cf373b3e21e9a1

How researchers see this paper

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In Immunology

1. R. Parker
2. Xiaohui S. Xie
3. Heiko Blaser
4. John J. Rossi
5. George A. Calin
6. N. Sharpless
7. J. Nemunaitis
8. A. Pasquinelli

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Gregory J. Hannon
5. Scott M. Hammond
6. P. Murphy
7. Leigh-Ann MacFarlane
8. T. Rana

Citations in the corpus

• MicroRNAS and their regulatory roles in plants. (2006, background): “The “slicer” activity guided by the miRNAs appears to reside in the Piwi domains of certain Argonaute proteins (76, 123), including Arabidopsis AGO1 (16, 112).”
• The role of PACT in the RNA silencing pathway (2006, background): “Argonaute proteins are the core components of the RISC (Hammond et al, 2001; Carmell et al, 2002; Liu et al, 2004; Meister et al, 2004; Sontheimer and Carthew, 2004).”
• Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “Their function in miRNA repression is demonstrated by their association with similar sets of miRNAs and their ability to repress protein synthesis when artificially tethered to the mRNA 3′ UT”
• Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005, neutral): “of RISC [29,31,34,35,36].”
• The highways and byways of mRNA decay (2007, background): “, and short interfering RNAs (siRNAs) initiate mRNA decay through endonucleolytic cleavage mediated by Argonaute protein-2 (AGO2”
• Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, background): “AGO1– 4, which are ubiquitously expressed in many tissues (Lu et al. 2005), recruit miRNAs (Liu et al. 2004).”
• Regulation of mRNA translation and stability by microRNAs. (2010, background): “A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.”
• Chemistry, structure and function of approved oligonucleotide therapeutics (2023, background): “Among the Ago family of proteins, Ago2 is the only one that possesses endonuclease activity (306,307).”
• Illuminating the silence: understanding the structure and function of small RNAs (2007, background): “Antisense siRNA in RISC serves as a guide for AGO2 (Ref”
• A human snoRNA with microRNA-like functions. (2008, background): “It has been reported that all Ago proteins bind miRNAs or siRNAs indiscriminately of their sequence (Liu et al., 2004; Meister et al., 2004).”