The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations.

By B. Agerberth, J. Charo, J. Werr, B. Olsson, F. Idali, L. Lindbom, R. Kiessling, H. Jörnvall, H. Wigzell, G. H. Gudmundsson. Blood, 2000

820 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/3c384608246a76832494dc074cc6624b106c2976

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

Robert E. W. Hancock

In Immunology

In Microbiology

Citations in the corpus

Skin immune sentinels in health and disease (2009, background): “Finally, they could contribute to antimicrobial defence by producing certain AMPs, such as cathelicidin”
Defensins: antimicrobial peptides of innate immunity (2003, background): “Although defensin expression by monocytes, macrophages and lymphocytes of some mammals can be detected by highly sensitive technique”
The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1 (2002, background): “The single known human cathelicidin, hCAP-18, is a major protein of the specific granules in neutrophils (18) and is also present in monocytes and certain lymphocyte populations ( 19 ), testis (20), human keratinocytes during inflammatory disorders (21), and airway epithelium (22).”
Antimicrobial peptides: key components of the innate immune system (2012, background): “In humans, LL-37 is expressed in neutrophils, macrophages (Rivas-Santiago et al., 2008), monocytes, B-cells, T-cells (Agerberth et al., 2000), and in most types of epithelial cells such as skin, lung (Frohm et al., 1997), seminal plasma (Malm et al., 2000), and epididymis (Sorensen et al., 2008) etc”
Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “LL-37 has chemotactic effects in vitro, inducing selective migration of human peripheral blood monocytes, neutrophils, and CD4 T cells [74, 96] with a dose-dependent, bell-shaped response, and optimal concentrations that range from 10 to 10 M.”
The cellular inflammatory response in human spinal cords after injury. (2006, methodology): “…ic.oup.com /brain/article-abstract/129/12/3249/267908 by guest on 15 M arch 2020 neutrophils (Schluesener and Meyermann, 1995; Barnathan et al., 1997; Agerberth et al., 2000) and was labelled by anti-NCLDefensin antibody (HNP 1–3) (1:1000, Novocastra Laboratories Ltd., Newcastle, UK).”