The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1

By M. Scott, D. Davidson, M. Gold, D. Bowdish, Robert E. W. Hancock. Journal of Immunology, 2002

763 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/aaa038d048d9a18cf534054a6a24c52a90fd0b02

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. Robert E. W. Hancock

In Immunology

1. M. Zanetti
2. A. Ramamoorthy
3. H. Jenssen
4. P. Hamill
5. M. Malmsten
6. A. Schmidtchen
7. Mukesh Pasupuleti
8. Robert E. W. Hancock

In Microbiology

1. M. Malmsten
2. A. Schmidtchen
3. Mukesh Pasupuleti
4. H. Jenssen
5. L. Ringstad
6. Joakim Håkansson
7. Camilla Björn
8. M. Mahlapuu

Citations in the corpus

• Antimicrobial peptides: key components of the innate immune system (2012, background): “, 1998), chemokine production (Territo et al., 1989; Chertov et al., 1996; Scott et al., 2002; Grutkoski et al., 2003), and anti-inflammatory properties (Turner et al.”
• Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “LL-37 exerts also chemoattractant effect on inflammatory cells (Chertov et al., 1996) and regulates secretion of proinflammatory cytokines (Scott et al., 2002; Niyonsaba et al., 2005; Mookherjee et al., 2006).”
• Peptide Antimicrobial Agents (2006, background): “upregulation of interferons and chemokines (24, 27, 37, 219),”
• Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 (2004, background): “These results indicate that 1,25(OH)2D3 alone or in conjunction with LPS can induce camp expression and release of antimicrobial activity in neutrophils.”
• Cathelicidins, multifunctional peptides of the innate immunity (2004, background): “Furthermore, systemic overexpression of this gene protects D-GalN-sensitized mice injected with LPS or E. coli from septic death [88], which suggests that LL-37 not only contributes to clearance of bacteria, it also offers systemic protection against the detrimental effects of massive microbial inva”
• Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form (2008, background): “In addition to broad spectrum of antimicrobial activity against bacteria (including mycobacteria), fungi, and viral pathogens (33, 40), LL-37 neutralizes endotoxin (LPS) (41) and functions as a chemoattractant for mononuclear cells and neutrophils (42).”
• LL-37, the only human member of the cathelicidin family of antimicrobial peptides. (2006, background): “Bowdish et al. showed that LL-37 and indolicidin synergistically suppress LPS-induced secretion of TNF-α from macrophage cell lines [159].”
• The P2X7 Receptor: A Key Player in IL-1 Processing and Release1 (2006, neutral): “LL-37 also exerts immunomodulatory activity, being chemoattractant for MN, T cells, and neutrophils (46) and up-regulates IL-8 and MCP1 in human whole blood (47).”