Latent enhancers activated by stimulation in differentiated cells.

By Renato Ostuni, Viviana Piccolo, I. Barozzi, S. Polletti, A. Termanini, S. Bonifacio, A. Curina, Elena Prosperini, S. Ghisletti, G. Natoli. Cell, 2013

794 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2ad38c2f9aed8f9b56e9112d39e6bbfef781a819

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Citations in the corpus

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription (2013, background): “Genes associated with newly selected enhancers marked by H3K4me1 in macrophages were recently shown to exhibit faster and stronger responses upon secondary stimulation (Ostuni et al., 2013).”
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment (2014, background): “Chromatin states, moreover, are stable within the time span of macrophage isolation (Experimental Procedures) (Garber et al., 2012; Ostuni et al., 2013); thus, the in vivo chromatin states are even less likely to be disrupted.”
Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “On the other side, long-term and more stable epigenetic marks contribute to define macrophage cell identity (55) and to the establishment of the so-called “epigenetic memory”, that influences macrophage response to subsequent microbe encounters (56).”
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin (2020, background): “For example, deposition of the histone modification H3K4me1 has been shown to prime regulatory elements, biasing cells for differentiation (Lara-Astiaso et al., 2014; Rada-Iglesias et al., 2011) or immune cell activation (Heinz et al., 2010; Ostuni et al., 2013).”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “Establishment of macrophage memory, depending on the experienced challenges, is likely to rely on epigenetic changes, as these can be at the basis of a rapid evolution of responsiveness and adaptation to incurring events, thereby allowing to surviving to new environmental threats (220, 225).”
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “Transcriptional changes from latent enhancers, rather than previously established enhancers, could resolve whether the DAM program is an immediate transcriptional response or a less anticipated response that requiresmore complex chromatin rearrangements (Ostuni et al., 2013).”
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance (2016, positive): “Mouse studies have shown that such distal element markings are important for appropriate responses to infection (Ghisletti et al., 2010; Ostuni et al., 2013) and identity of tissueresident macrophages (Amit et al., 2016; Lavin et al., 2014).”