Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.

By Linda Holmquist-Mengelbier, E. Fredlund, Tobias Löfstedt, R. Noguera, S. Navarro, Helén Nilsson, A. Pietras, J. Vallon-Christersson, Å. Borg, K. Gradin and 2 more. Cancer Cell, 2006

723 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/3b6e95c758455f70d292f6e853a14e13d5b2c070

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Craig B. Thompson

Citations in the corpus

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. (2007, background): “For example, HIF-2α appears to be stabilized at higher O2 levels (5%), and for longer time periods, than HIF-1α in neuroblastoma (Holmquist-Mengelbier et al., 2006).”
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. (2007, background): “In recent studies of neuroblastoma and colorectal and non-small-cell lung cancer, which express both a subunits, the expression of HIF-2a was more conclusively associated with a poor prognosis than HIF-1a (Giatromanolaki et al., 2001; Holmquist-Mengelbier et al., 2006; Yoshimura et al., 2004).”
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “Collectively, these results suggest that the net effect of HIFa on tumor growth is context dependent and influenced by variables such as cell of origin and tumor location, which in turn might influence factors such as the interplay between HIF1a and HIF2a.”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Interestingly, HIF-2α-positive neuroblastoma cells have been identified in perivascular niches (Holmquist-Mengelbier et al., 2006; Pietras et al., 2008), indicating that HIF-2α protein is stabilized in these cells despite sufficient oxygen and facilitating the pseudohypoxic phenotype in tumor cells.”
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, positive): “As in previous reports (Keith and Simon, 2007; Holmquist-Mengelbier et al., 2006), HIF2a knockdown was selectively associated with reduced mRNA levels of Glut1 and SerpinB9, whereas targeting HIF1a significantly decreased PGK1 mRNA (Figure S11).”
The impact of O2 availability on human cancer (2008, background): “Finally, downregulating HIF2α through RNA interference resulted in decreased subcutaneous neuroblastoma growt”