Obesity alters gut microbial ecology.

By Ruth E. Ley, F. Bäckhed, Peter J. Turnbaugh, Catherine A. Lozupone, Robin D. Knight, Jeffrey I. Gordon. Proceedings of the National Academy of Sciences of the United States of America, 2005

6,021 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/3b437b1b2b608a13d7011e9a13c2f6b94e5eded8

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Citations in the corpus

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment (2011, positive): “Hence, obesity could be transferred by the intestinal microbiota (Backhed et al, 2004, 2005; Ley et al, 2005, 2006; Turnbaugh et al, 2006, 2007).”
Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “Obese mice, either genetically predisposed or diet-induced, tend to display an increase in Firmicutes and a decrease in Bacteriodetes [185–189].”
Unravelling the effects of the environment and host genotype on the gut microbiome (2011, background): “Several studies have shown that genetically identical mice from the same litters have a more similar microbiota than mice from different litters, even though they may be reared in adjacent cage”
Ecological and evolutionary forces shaping microbial diversity in the human intestine. (2006, positive): “The largest data sets consist of 13,335 16S rRNA sequences from three healthy adult humans (Eckburg et al., 2005) and 5,088 sequences from 19 adult mice belonging to the commonly used C57Bl/6 inbred strain ( Ley et al., 2005 ).”
Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity (2017, background): “…health conditions from preterm birth to type 2 diabetes, obesity and even cancer are being linked to microbiome diversity (Peek and Blaser, 2002; Ley et al., 2005; Turnbaugh et al., 2006; Blaser et al., 2008; Gao et al., 2008; Islami and Kamangar, 2008; Garrett et al., 2010; Tana et al., 2010;…”
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice (2008, background): “These animals are characterized by different gut microbiota (8,12), higher inflammatory tone, and endotoxemia when compared with wild-type mice (23).”
UniFrac – An online tool for comparing microbial community diversity in a phylogenetic context (2006, methodology): “The UniFrac metric has been used to cluster many different environments according to shared similarities in community composition [3,11].”
Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance (2013, result): “Gordon and colleagues have reported that human obesity is associated with a low abundance of intestinal Bacteroidetes and a high abundance of Firmicutes, in agreement with results from a weight-loss program involving consumption of restricted diets for a year [9–11].”
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “For example, the relative proportion of commensals of the order Bacteroidales is reduced in obese individuals and in inbred mouse strains that are genetically predisposed to obesit”
The Effects of Vegetarian and Vegan Diets on Gut Microbiota (2019, background): “Further research is needed to determine whether the increase in energy harvest due is due to the Bacteroidetes:Firmicutes ratio promoting adiposity or representing a host-mediated adaptive response to limit energy uptake (42).”
Quantitative and Qualitative β Diversity Measures Lead to Different Insights into Factors That Structure Microbial Communities (2007, methodology): “microbial community composition in the mouse gut (11).”
Comparative Analysis of Human Gut Microbiota by Barcoded Pyrosequencing (2008, background): “The recent demonstration that obesity is reflected in the intestinal microbial composition in both mice [30] and humans [10], and that the obesity trait is transmissible through transplantation of the microbiota [3] clearly illustrates how the microbial community can effect host physiology.”
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models (2006, methodology): “Some of the largest published ML-based analyses to date have been conducted with RAxML (Robertson et al., 2005; Ley et al., 2005, 2006 ).”
Dysbiosis of the gut microbiota in disease (2015, background): “Metabolic disorders An increase in the relative abundance of Firmicutes and a reduction in the level of Bacteroidetes have been observed in both obese mice (44) and humans (45) although these findings have not been replicated in all studies (46 52).”