Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

By Patrice D Cani, R. Bibiloni, C. Knauf, A. Waget, A. Neyrinck, N. Delzenne, R. Burcelin. Diabetes, 2008

4,549 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/759817dfccf58d2ad0b1cbfe8dfe2931dc464d76

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Molecular Biology

In Neurology

Citations in the corpus

Gut microbiome, obesity, and metabolic dysfunction. (2011, background): “Prebiotic carbohydrates and/or antibiotics lowered systemic endotoxin levels and inflammatory cytokine expression in the liver (50).”
Metabolic effects of fructose and the worldwide increase in obesity. (2010, background): “Low-grade endotoxinemia in turn activates inflammatory pathways and impairs insulin’s action, leading to the development of insulin resistance (39, 40).”
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “Penetration of lipopolysaccharide into the bloodstream is controlled by the integrity of the gut barrier.(48) Administration of A muciniphila has been shown to prevent the thinning of mucus layer in mice with diet-induced obesity.”
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “Furthermore, rodent models indicated that the gut microbiome is vital in increasing inflammatory tone in obesity and T2DM (129).”
Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice (2011, methodology): “Food was removed 2 h after the onset of the daylight cycle, and mice were treated after a 6-h fasting period as previously described (6,7).”
Pathophysiology of Atherosclerosis (2022, background): “In addition, gut dysbiosis increases intestinal permeability, reducing the expression of tight junction proteins and allowing the translocation of lipopolysaccharides that induce low-grade inflammation via Toll-like receptors [354].”
Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, background): “Furthermore, an interesting animal model, the immunoprotein CD14 knockout ob/ob mouse, which is unable to induce LPS-mediated inflammatory pathways, was resistant to weight gain and was insulin-hypersensitive, despite being fed with the same diet as leptin-deficient ob/ ob mice [60].”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “This metabolic endotoxemia is associated with increased body fat, glucose intolerance, and increased expression of proinflammatory mediators and macrophage infiltration in white adipose tissue [60].”