Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance
By Xiuying Zhang, Dongqian Shen, Zhiwei Fang, Zhuye Jie, Xinmin Qiu, Chunfang Zhang, Yingli Chen, L. Ji. PLoS ONE, 2013
832 citations recorded by the source corpus.
To explore the relationship of gut microbiota with the development of type 2 diabetes (T2DM), we analyzed 121 subjects who were divided into 3 groups based on their glucose intolerance status: normal glucose tolerance (NGT; n = 44), prediabetes (Pre-DM; n = 64), or newly diagnosed T2DM (n = 13). Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. T2DM-related dysbiosis was observed, including the separation of microbial communities and a change of alpha diversity between the different glucose intolerance statuses. To assess the correlation between metabolic parameters and microbiota diversity, clinical characteristics were also measured and a significant association between metabolic parameters (FPG, CRP) and gut microbiota was found. In addition, a total of 28 operational taxonomic units (OTUs) were found to be related to T2DM status by the Kruskal-Wallis H test, most of which were enriched in the T2DM group. Butyrate-producing bacteria (e.g. Akkermansia muciniphila ATCCBAA-835, and Faecalibacterium prausnitzii L2-6) had a higher abundance in the NGT group than in the pre-DM group. At genus level, the abundance of Bacteroides in the T2DM group was only half that of the NGT and Pre-DM groups. Previously reported T2DM-related markers were also compared with the data in this study, and some inconsistencies were noted. We found that Verrucomicrobiae may be a potential marker of T2DM as it had a significantly lower abundance in both the pre-DM and T2DM groups. In conclusion, this research provides further evidence of the structural modulation of gut microbiota in the pathogenesis of diabetes.
Subfields: Infectious Diseases, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/5a88bffdb8ae2f69a75f221418f926902901bfff
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Infectious Diseases
In Molecular Biology
In Physiology
Citations in the corpus
- Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “This conclusion was supported by the highest abundance of Roseburia (OTU1900), Akkermansia muciniphila ATCCBAA-835, and Fecalibacterium prausnitzii L2-6 in normal glucose tolerance subjects [104].”
- Personalized Nutrition by Prediction of Glycemic Responses. (2015, background): “Pioneering work by Jeffrey Gordon and colleagues previously showed that it associates with the propensity for obesity and its complications, and later works also demonstrated associations with glucose intolerance, TIIDM, hyperlipidemia, and insulin resistance (Le Chatelier et al., 2013; Karlsson et ”
- Akkermansia muciniphila is a promising probiotic (2019, background): “Another study found that the abundance of A. muciniphila was reduced in subjects with pre-diabetes and type 2 diabetes compared to subjects with normal glucose tolerance (Zhang et al., 2013).”
- Role of gut microbiota in type 2 diabetes pathophysiology (2020, background): “On one hand, consistent findings have been reported in 5 studies on Ruminococcus genus [3,17,28,31,81] and 3 studies on Fusobacterium [2,4,6].”
- Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila (2017, background): “…muciniphila was decreased in several pathological situations such as obesity, type 2 diabetes, inflammatory bowel diseases, hypertension and liver diseases (Png et al., 2010; Belzer and de Vos, 2012; Zhang et al., 2013; Dao et al., 2015; Yassour et al., 2016; Grander et al., 2017; Li et al., 2017).”