Living with the Past: Evolution, Development, and Patterns of Disease

By Peter D. Gluckman, Mark A. Hanson. Science, 2004

1,897 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/3a93bed68c2d108c3777dbb2bb3929a414db54a4

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Citations in the corpus

Inflammation 2010: new adventures of an old flame. (2010, background): “In other words, the intended, beneficial role of this mode 774 Cell 140, March 19, 2010 ©2010 Elsevier Inc. of adaptation can become detrimental because of the mismatch between the current environment and the evolutionary pressures of the past (Gluckman and Hanson, 2004).”
The Timing of Prenatal Exposure to Maternal Cortisol and Psychosocial Stress is Associated with Human Infant Cognitive Development (2010, background): “Birth phenotype, instead, reflects fetal adaptation to exposures that shape the structure and function of physiological systems that underlie health and disease risk (Gluckman & Hanson, 2004; Morley, Blair, Dwyer, & Owens, 2002).”
Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. (2008, background): “It has been hypothesized that the molecular mechanisms underlying this phenomenon may in part be related to epigenetic modulation of expression of key developmental genes (2, 3).”
Prenatal exposure to maternal depression and cortisol influences infant temperament. (2007, background): “It has become increasingly evident that the origins of many illnesses begin in fetal life and that prenatal events have beneficial and harmful effects on health (Gluckman and Hanson, 2004).”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “In either case, they lead to mature individuals who have followed a developmental trajectory appropriate for a lower energy environment but who find themselves in a high energy environment and with physiological and structural adaptations that are now inappropriate and associated with a greater prop”
Neonatal leptin treatment reverses developmental programming. (2005, background): “Gluckman and Hanson (2) have suggested that developmen-”
Predictive adaptive responses and human evolution. (2005, background): “In humans, such incorrect predictions are revealed as an increased disease risk [ 7 ].”
Instrumental Variable Estimation of the Causal Effect of Hunger Early in Life on Health Later in Life (2016, positive): “Effects of foetal undernutrition on metabolic adaptation in utero may affect the phenotype such that the risk of cardiovascular disease later in life is increased (Hales and Barker, 1992; Bateson, 2001; Gluckman and Hanson, 2004).”
Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology (2007, background): “Such persistent effects of developmental plasticity, which are constrained by the genome but not determined by classical DNA-sequence-related genetic mechanisms, have been proposed to help optimize the fitness of the organism to its predicted environment”
Frailty: an emerging research and clinical paradigm--issues and controversies. (2006, background): “, type 2 diabetes) depends in part on environmental influences and behaviors in early life (51).”
Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. (2017, background): “Early alterations of biological systems may have an adaptive value and may reflect anticipatory adaptations to projected demands (Gluckman and Hanson, 2004).”