Mechanisms of Disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology

By J. Seckl, M. Holmes. Nature Clinical Practice Endocrinology &Metabolism, 2007

765 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/c3c8910c43c31ec76a346fc974c8f3f5ea8b17ef

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In Endocrinology, Diabetes and Metabolism

In Nutrition and Dietetics

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Early Life Programming and Neurodevelopmental Disorders (2010, background): “Prenatal glucocorticoid overexposure produces long-term changes in offspring cardiometabolic, neuroendocrine, and behavioral outcomes via tissue-specific effects on gene promoter epigenetic changes (45).”
Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. (2017, background): “The ‘fetal programming hypothesis’ (Seckl and Holmes, 2007), the ‘developmental programming hypothesis’ (Barker, 2004; Langley-Evans, 2006; Langley-Evans, 2015), and the ‘Developmental Origins of Health and Disease (DOHaD) hypothesis’ (Barker, 2004; Barker,”
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “11 -HSD1 induction in the late gestation lung may help its maturation without unwanted systemic glucocorticoid effects such as developmental programming (625).”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “…can stably alter, or program, the transcription of genes in the liver and other sites that are associated with glucose and fat metabolism, including the gene for the glucocorticoid receptor (Bateson et al., 2004; Gluckman & Hanson, 2004, 2007; Meaney, Szyf, & Seckl, 2007; Seckl & Holmes, 2007).”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “Collectively, the results of such studies provide support for the notion that glucocorticoids are intimately linked with fetal programming of adult pathophysiology (482) (see also Section VIII.”
The Psychological Impact of Child Soldiering (2010, background): “…for offspring, whose mothers were stressed during pregnancy, derives from evidence gained in experimental biology, as intrauterine stress shows to affect neurodevelopment in animals, which are thought to be relevant to cognition, aggression, anxiety, and depression in humans (Seckl & Holmes, 2007).”
STRUCTURAL RACISM AND HEALTH INEQUITIES (2011, background): “For instance, research indicates that stressors encountered by parents while an infant is in utero may increase the risk of heart disease and other illnesses when the child becomes an adult (Barker 2002; Seckl and Holmes, 2007).”