Functions of heparan sulfate proteoglycans in cell signaling during development

By Xinhua Lin. Development, 2004

700 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3a1b1e5c24239e6b54de96b482606fd50e27a491

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Citations in the corpus

Hedgehog Signaling in Development and Cancer (2008, neutral): “HSPGs are not speciﬁc for Hh signaling, regulating other signaling molecules including Wnt/Wg and Dpp/TGF-b (Lin, 2004).”
The endothelial glycocalyx: composition, functions, and visualization (2007, background): “(2) Binding of plasma-derived molecules to the glycocalyx can lead to a local concentration gradient, which is often seen in growth factor-regulated gene transcription and developmental processes [61, 82].”
Wnt/beta-catenin signaling in development and disease. (2006, neutral): “, and Lin, R. (2004). Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C.”
Role of platelet-derived growth factors in physiology and medicine. (2008, neutral): “PDGFs bind to heparin and HSPGs similar to many other growth factors and morphogens with critical functions during development (e.g., hedgehogs, bone morphogenetic protieins [BMPs], and Wnts) (Feyzi et al. 1997; Lustig et al. 1999; Lin 2004; Häcker et al. 2005; Abramsson et al. 2007).”
Cysteine‐rich domains related to Frizzled receptors and Hedgehog‐interacting proteins (2012, background): “They are attached to the outer leaflet of the plasma membrane by a C-terminal GPI anchor and play important roles in regulating the distribution and signaling of various morphogens including Hedgehog, Wnt, FGF, and BMP.(54,55) Drosophila and human have two (Dally and Dally-like) and six (glypican 1–”
Extracellular Matrix Communication and Turnover in Cardiac Physiology and Pathology (2015, neutral): “Among growth factors, transportation of fibroblast growth factors (FGFs) through proliferation, survival, migration and differentiation during development, growth, and in disease (222, 307, 326, 378, 496).”
FGF/FGFR signaling in health and disease (2020, background): “The interaction also provides a depot of regulatory factors that can be released by selective degradation of the HS chains facilitating the formation of FGF gradients essential for cell specification during development and regeneration.(22) Structural studies have revealed that the HSPG binding site”
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. (2006, background): “In addition, heparan sulfate-modifided proteoglycans are involved in Wnt signaling, possibly by regulating the extracellular transport of Wnt (Hacker et al., 2005; Lin, 2004).”