The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease
By D. Chabas, Sergio E. Baranzini, D. Mitchell, C. Bernard, S. Rittling, D. Denhardt, R. Sobel, C. Lock, M. Karpuj, R. Pedotti and 3 more. Science, 2001
900 citations recorded by the source corpus.
Subfields: Cell Biology, Developmental Neuroscience, Rheumatology
View Paper: https://www.semanticscholar.org/paper/38f3d78e5ad81be343403f4a9978e2d2496d31b6
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Citations in the corpus
- Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size (2005, background): “For example, granulomatous responses are associated with high levels of OPN expression (16, 17, 20) and OPN can function as a Th1 cell cytokine, enhancing IL-12 while inhibiting expression of the Th2 cell cytokine IL-10 (17, 19, 21).”
- TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. (2014, neutral): “…0.0001 (Martinez et al., 2006) Mif MIF 4 M1 inducer 0.0001 (Mitchell et al., 2002; Yaddanapudi et al., 2013) Spp1 Osteopontin 2 Th1 cytokine 0.02 (Chabas et al., 2001) Anti-inflammatory IL1rn IL1ra 309 M2 cytokine 0.02 (Mantovani et al., 2004) Ccl12 CCL12 216 M2 cytokine 0.03 (Murray and Wynn,…”
- Extracellular matrix: a dynamic niche component during cancer progression (2012, positive): “Additionally, the ECM plays an impor tant role in immune cell differentiation, including the maturation process of T helper cells (Chabas et al., 2001; Hur et al., 2007).”
- New concepts in the immunopathogenesis of multiple sclerosis (2002, neutral): “Initial studies using MICROARRAY technology and large-scale sequencing of complementary DNA libraries from MS and control tissue have identified many new molecules that are up- or downregulated in MS lesion”
- Multiple sclerosis: a complicated picture of autoimmunity (2007, background): “, and it is abundantly expressed in multiple sclerosis lesion”
- A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model (2013, neutral): “Osteopontin may be neurotoxic or neuroprotective, as it has been shown to contribute to disease progression in autoimmune encephalomyelitis (Chabas et al., 2001) and is upregulated in AD cerebral spinal fluid, but is neuroprotective in animal models of spinal cord injury (Comi et al.”
- The impact of the extracellular matrix on inflammation (2010, background): “It was first identified as a factor in multiple sclerosis by large-scale sequencing of cDNA libraries derived from perivascular cuffs that were dissected from the brains of patients with multiple sclerosi”