Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.
By Charles J. David, J. Manley. Genes & Development, 2010
813 citations recorded by the source corpus.
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It provides cells with the opportunity to create protein isoforms of differing, even opposing, functions from a single gene. Cancer cells often take advantage of this flexibility to produce proteins that promote growth and survival. Many of the isoforms produced in this manner are developmentally regulated and are preferentially re-expressed in tumors. Emerging insights into this process indicate that pathways that are frequently deregulated in cancer often play important roles in promoting aberrant splicing, which in turn contributes to all aspects of tumor biology.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/41e89e9c4b088bc6cdcf6682caf62ada6f9b1442
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Citations in the corpus
- Mechanisms and Regulation of Alternative Pre-mRNA Splicing (2015, background): “Thus, somatic mutations in genes encoding well-studied splicing factors are correlated with at least two types of cancer, indicating that aberrant splicing patterns are directly linked to the disease phenotype (39, 99).”
- TCGASpliceSeq a compendium of alternative mRNA splicing in cancer (2015, background): “Inclusion of this exon was found to be increased in colorectal cancer and to play a role in metastasis (2).”
- A highly conserved program of neuronal microexons is misregulated in autistic brains (2014, background): “It is also widely established that misregulation of AS plays important roles in altering the growth and invasiveness of various cancers (David and Manley, 2010).”
- RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES (2011, neutral): “Alternative splicing has been described for a wide range of cancers 30,31 , although the underlying mechanisms that influence cancer pathogenesis remain largely unknown.”