Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
By H. Puthalakath, A. Villunger, L. O’Reilly, J. Beaumont, Leigh Coultas, R. Cheney, David C. S. Huang, A. Strasser. Science, 2001
672 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/37ff94e143e2e01a3054bdd16fd402fff33051ea
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In Molecular Biology
- Guido Kroemer
- Douglas R. Green
- Jerry M. Adams
- L. Galluzzi
- Suzanne Cory
- A. Strasser
- J. Chipuk
- Junying Yuan
Citations in the corpus
- Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. (2008, background): “Overexpression of Bmf has been shown to reduce the colony formation of L929 cells (Puthalakath et al., 2001); however, the mechanism by which Bmf induces the death of L929 cells has not been directly examined.”
- Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario (2006, background): “For example, BMF also binds to myosin motor complexes (DLC2) and thus may detect similar cytoskeletal changes as BIM.25 However, activation of BH3-only proteins is probably not sufficient to ensure that every cell will initiate MOMP.”
- The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “In an analogous way, Bmf is bound to the myosin V motor complex through interaction with DLC2 (Puthalakath et al., 2001).”
- ER stress triggers apoptosis by activating BH3-only protein Bim. (2007, background): “Bim and Bmf can be regulated by their interaction with DLC1 or DLC2 dynein light chains, which causes their sequestration to the microtubular dynein motor complex or the actin-bound myosin V motor complex, respectively (Puthalakath et al., 1999, 2001).”
- Bcl-2-family proteins and the role of mitochondria in apoptosis. (2003, background): “Bim and Bmf are normally localized in specific cytoskeletal compartments — Bim on microtubules through interaction with dynein light chain 1 [45], and Bmf on myosin V motor complexes through dynein light chain 2 [44].”