Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

By J. Chipuk, L. Bouchier-Hayes, Douglas R. Green. Cell Death and Differentiation, 2006

614 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/872e0c949646eafeb456fd9c670ca85677d2dc05

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In Molecular Biology

1. T. Mak
2. Douglas R. Green
3. Guido Kroemer
4. L. Galluzzi
5. Simone Fulda
6. J. Wells
7. Olivier Julien
8. Jerry M. Adams

Citations in the corpus

• Cytochrome c: functions beyond respiration (2008, background): “The OMM is not usually permeable to proteins, and the decisive event that signifies the 'point of no return' in the sequence that leads to the death of the cell is mitochondrial outer membrane permeabilization (MOMP”
• The molecular machinery of regulated cell death (2019, neutral): “, cytochrome C, somatic [CYCS], diablo IAP-binding mitochondrial protein [DIABLO, also known as Smac], and HtrA serine peptidase 2 [HTRA2]) and subsequent activation of initiator caspase CASP9.(8) MOMP is tightly controlled by the BCL2 family, including pro-apoptotic (e.”