Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
By L. Ho, W. Qin, P. Pompl, Z. Xiang, Jun Wang, Zhong Zhao, Yuanzhen Peng, G. Cambareri, Anne B. Rocher, C. Mobbs and 2 more. The FASEB Journal, 2004
644 citations recorded by the source corpus.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Physiology
View Paper: https://www.semanticscholar.org/paper/37ca2b2234cbf822dd38c8dcd0f9e7290f32cd71
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Citations in the corpus
- Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “Thus, injection of insulin increased GSK3 phosphorylation in mouse brain [131] and brain GSK3 phosphorylation was reduced by blockade of insulin signaling by knockout of the insulin receptor [132] and in mice with diet-induced insulinresistance [133].”
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. (2010, background): “Introduction Insulin like growth factor-1 receptor (IGF-1R) and insulin eceptor (IR) are closely related members of a transmembrane etrameric (2 , 2 ) tyrosine kinase receptor family, whose ignalling pathways control vital brain functions.”
- Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. (2012, background): “Moreover, peripheral insulin resistance without T2D is a risk factor for AD (8, 14) within 3 years of diagnosis (14); is a common feature of AD cases (15); and is associated with reduced basal (16) and insulin-induced (17, 18) activation of cerebral IRs, higher cerebral neuritic plaque loads (16, 19”
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers (2009, background): “Experimentally induced diabetes moreover causes AD mice models to exhibit accelerated cognitive failure (32, 33).”