Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.

By K. Talbot, Hoau Yan Wang, H. Kazi, Li-ying Han, K. Bakshi, A. Stucky, Robert L. Fuino, Krista R. Kawaguchi, Andrew Samoyedny, R. Wilson and 6 more. Journal of Clinical Investigation, 2012

1,731 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b13e6ac57e0987c35f9bd9bd687539ede9d470d7

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Citations in the corpus

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Patients with AD exhibit reduced expression and activation of IR, IGF-1R, and IRS-1 proteins in the brain, in particular in the hippocampus and hypothalamus, as well as increased serine phosphorylation in IRS-1, which is generally regarded as inhibitory (78,79).”
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “Some investigators even called AD as ''Type 3 diabetes mellitus'' or ''brain insulin resistance''(de la Monte, 2012; Talbot et al., 2012; de la Monte and Wands, 2008; Steen et al., 2005).”
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “Therefore, the balance between IRS phosphorylation at serine or tyrosine residues (IRS-1pSer vs. IRS-1pTyr) determines the extent of insulin actions.”
The Gut Microbiota and Alzheimer’s Disease (2017, positive): “More speciﬁcally, it has been suggested that brain insulin resistance may characterize AD and promote cognitive decline [134].”
Neuroinflammation in Alzheimer's disease: Current evidence and future directions (2016, background): “The response to insulin and to insulin-like growth factor 1 (IGF-1) in the signaling pathway appeared reduced in those subjects, suggesting that insulin resistance is a common feature of AD [71].”
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “The insulin receptor signaling system plays an important role in maintaining normal brain and cognitive functions(84) by regulating GLP-1 receptors,(84,85) insulin receptor substrate (IRS) receptors.(86,87) In other tissues, insulin activates the glucose transporter (GLUT) family of glucose transpor”
Religious Orders Study and Rush Memory and Aging Project (2018, positive): “Interestingly, we found that insulin resistance in brain was related to measures of AD pathology [214].”