Neuronal or glial progeny: regional differences in radial glia fate.

By P. Malatesta, M. Hack, Eva Hartfuss, Helmut Kettenmann, W. Klinkert, F. Kirchhoff, M. Götz. Neuron, 2003

796 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/373db3f6d79f710e081a053e820383ff88f8372d

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Citations in the corpus

Neurogenesis in the Adult Hippocampus. (2015, background): “Glial features also characterize neural stem cells in the embryonic brain (Noctor et al. 2001, 2002; Heins et al. 2002; Malatesta et al. 2003) and the other neurogenic area in the adult brain, the SVZ (Doetsch et al.”
Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “Gfap, it seems, was chosen even though it is often expressed by progenitor cells (Malatesta et al., 2003), and in disregard of other intermediate filaments, such as vimentin and nestin, that are also upregulated in reactive astrocytes.”
Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “Two developmental lineage studies identified glial fibrillary acidic protein (GFAP) and brain lipid-binding protein (BLBP) as functional stem cell markers during embryonic brain development (Anthony et al., 2004; Malatesta et al., 2003).”
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis (2005, background): “Radial glia can be labeled by an injection of tracer at a distance from the cell bodies in the VZ, in regions traversed by their long processes (Voigt, 1989; Malatesta et al., 2000, 2003 ).”
Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex (2005, background): “Unlike radial glia, progenitors in the SVZ express Svet1 but do not express Pax6, GLAST, or hGFAP-Cre transgene (Götz et al., 1998; Tarabykin et al., 2001; Malatesta et al., 2003).”
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain (2004, methodology): “Cell fate mapping using Cre/ loxP recombination and activation of reporter gene expression, as done here, has been validated in previous studies from several laboratorie”
Neuronal subtype specification in the cerebral cortex (2007, background): “As neurogenesis progresses, they transform into radial glia, which share some but not all antigenicity with the early neuroepithelial cell”
Radial glia serve as neuronal progenitors in all regions of the central nervous system. (2004, background): “Rosa26 in the postnatal brain (and therefore which are the hGFAP promoter (Malatesta et al., 2003) ,”
The Sox9 transcription factor determines glial fate choice in the developing spinal cord. (2003, background): “Additionally, astrocytes appear to be generated by transdifferentiation of radial glia (Bignami and Dahl 1974; Malatesta et al. 2003), pointing to a heterogeneous origin of astrocytes.”
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, result): “The concept of radial glia-like cells serving as stem cells in the adult hippocampus is in line with similar reports from fetal brain development (Heins et al., 2002; Malatesta et al., 2003; Noctor et al., 2001, 2002) and the adult subventricular zone (Doetsch et al., 1997; Scheffler et al., 2005).”
Tumorigenesis in the brain: location, location, location. (2007, background): “In this regard, studies in which the fate of specific RG populations are traced genetically in vivo ( 11 ), ex vivo studies of RG differentiation (12), and live time-lapse video microscopy studies (13) collectively suggest that dorsal and ventral telencephalic RG”
Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation (2007, background): “Additional studies in our and other laboratories confirmed gfa2 activity in GFAP-expressing progenitor cells that give rise to astrocytes, oligodendrocytes, and neurons (Malatesta et al., 2003; Casper and McCarthy, 2006).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “…of the human GFAP promoter, which is expressed by RG at a slightly later stage, failed to label neurons derived from the ventral telencephalon (Malatesta et al. 2003), possibly because the hGFAP promoter may not be active ventrally in the mouse until later stages of development (Anthony et…”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “However, a small but significant increase in the number of oligodendrocytes, identified by the antigen Adenomatous polyposis coli (APC ) (McTigue et al., 2001; Ding et al., 2003; Malatesta et al., 2003), could be observed after interference with Dlx2-mediated transactivation (Fig.”
Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo (2009, background): “For example, it has been shown for another ROSA26-based reporter line (ROSA26loxP-STOP-LoxP-LacZ) [32] that this labels differentiated astrocytes poorly [2,4].”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “In CNS neurogenesis, for example, radial glial cells have been identified as progenitors that can differentiate into diverse neuronal subtypes (Goldman, 2003; Gotz and Barde, 2005).”