GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

By D. R. Garcia, N. Doan, T. Imura, T. Bush, M. Sofroniew. 2004

1,024 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum (2006, background): “…after cerebral ischemia Previous studies have shown that SVZ GFAP-expressing cells include a neurogenic cell population, which gives rise to neuroblasts that migrate anteriorly in the RMS and differentiate into neurons in the OB (Doetsch et al., 1999; Garcia et al., 2004; Imura et al., 2006).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “This manipulation led to a substantial reduction of neurogenesis after Ganciclovir injection (Garcia et al. 2004; Saxe et al. 2006, 2007).”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “QNPs encompass the majority of neuron-producing stem cell activity in the adult DG and overlap to a large degree with other varieties of hippocampal stem cells which have been identified structurally, functionally, or by expression of other reporters (Eckenhoff and Rakic, 1984; Garcia et al., 2004; ”
A Neurovascular Niche for Neurogenesis after Stroke (2006, methodology): “In this line, GFP is produced in any cell that has expressed GFAP and then turned off this gene or is currently expressing GFAP (Garcia et al., 2004).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “2005) and act as neural stem cells in the adult brain (Doetsch et al. 1999a; Laywell et al. 2000; Imura et al. 2003; Morshead et al. 2003; Garcia et al. 2004; Sanai et al. 2004; Ahn & Joyner 2005).”
The therapeutic potential of neural stem cells (2006, background): “1a ), which contain slowly-proliferating putative CNS stem cells immunoreactive for glial fibrillary acidic protein (GFAP), nestin, and, eventually, the radial glia marker RC2 (Ref”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, positive): “Consistent with observations in development and in the adult SVZ, radial astrocytes in the SGZ function as the primary precursors of the new neurons in the dentate gyrus (Seri et al. 2001, Fukuda et al. 2003, Garcia et al. 2004, Steiner et al. 2004).”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “The transcription factor Sox2 is important for maintaining the ‘‘stemness’’ not only of certain types of adult stem cells including NSCs but also of embryonic stem (ES) cells; as part of a four-factor cocktail, Sox2 contributes to inducing adult somatic cells to take on an ES cell-like fate (see Rev”
Astrocytes: a central element in neurological diseases (2016, neutral): “selves which also express GFAP [68, 198].”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “progenitors as the primary source of adult neurogenesis (Denise et al., 2004).”
The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain (2018, neutral): “restrict expression to astrocytes) (Garcia et al., 2004).”