Gout-associated uric acid crystals activate the NALP3 inflammasome

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The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA (2009, background): “It has been established that NLRP3 responds to both microbe-associated molecules and damageassociated molecular patterns (DAMPS) such as uric acid, alum salt, and silica (Dostert et al., 2008; Eisenbarth et al., 2008; Hornung et al., 2008; Li et al., 2008; Martinon et al., 2006).”
A Proposed Classification of the Immunological Diseases (2006, result): “]. At a molecular level, attacks of gout are associated with activation of the IL-1s signalling cascade, via the NALP3 inflammasone, in a manner similar to some of the HPFs [”
Inflammation in prostate carcinogenesis (2007, background): “In support of this, recent work has implicated crystalline uric acid as a 'danger signal' released from dying cells, and it has been shown to directly engage the caspase-1-activating NALP3 (cyropyrin) inflammasome present in cells of the innate immune system (primarily macrophages), resulting in t”
NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis. (2018, background): “In gout, monosodium urate crystals deposited within the joints potently activate the NLRP3 inflammasome.(133) Type 2 diabetes mellitus is generally associated with increased levels of inflammatory cytokines, including IL-1β.”