Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.

By P. Ducy, M. Amling, S. Takeda, M. Priemel, A. Schilling, F. Beil, Jianhe Shen, C. Vinson, J. Rueger, G. Karsenty. Cell, 2000

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Endocrine regulation of male fertility by the skeleton. (2011, positive): “Based on physiological and clinical observations, we hypothesized ten years ago that bone mass, energy metabolism and reproduction might be coordinately regulated (Ducy et al., 2000).”
Relationship of obesity with osteoporosis. (2007, background): “Based on these observations, it was proposed that leptin may inhibit bone formation (8).”
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors (2004, neutral): “osteogenic (30), whereas leptin is antiosteogenic (11, 13, 31), nei-”
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an entero-bone endocrine axis (2008, methodology): “Histology, Protein Expression, and Proliferation Assays Immunohistochemistry was performed according to standard protocols on specimens embedded in paraffin and sectioned at 6 mm (Ducy et al., 2000).”
Leptin regulates bone formation via the sympathetic nervous system. (2002, methodology): “(Sigma) at 8 ng/hr or MT-II at 125 ng/hr (Phoenix Pharmaceuticals) for 28 days (Ducy et al., 2000).”
Caloric restriction. (2011, background): “In fact this seems to be exactly what happens (Duffy et al., 1989; Masoro et al., 1992) (Fig.”